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Your Brain On

Drs. Ayesha and Dean Sherzai
Your Brain On
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  • Your Brain On... Autism
    Autism isn’t new, but our understanding of it has changed dramatically. It’s now recognized as a broad neurodevelopmental spectrum that shapes how millions of people perceive, process, and interact with the world. In this episode, we explore what autism is AND isn’t, from its earliest signs in infancy to its deep genetic roots, and why misinformation about it continues to spread. We speak with three remarkable experts leading the field in early detection, genetics, and public education: DR. AMI KLIN, PhD, Director of the Marcus Autism Center at Emory University and a pioneer in early autism research, whose work shows autism can be identified in babies as young as two months old. DR. JOSEPH BUXBAUM, PhD, Director of the Seaver Autism Center at Mount Sinai and a global leader in autism genetics, uncovering hundreds of genes linked to the condition. DR. ANDREA LOVE, immunologist, microbiologist, and founder of ImmunoLogic, known for her clear, evidence-based communication about vaccines, immunity, and autism myths. Together, we discuss: • What autism really is, and how the definitions have evolved • How it develops in infancy (and why early diagnosis can be so critical) • The powerful genetic evidence behind autism • The persistence of vaccine myths, and how misinformation spreads • How technology like eye-tracking can detect autism early • The rise of “profound autism” and what it means for families • The future of genetics-based treatments and therapy Whether you’re autistic yourself, a parent navigating a new diagnosis, or simply seeking understanding, we’re thrilled to share this extensive, in-depth episode with you. This is... Your Brain On Autism. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/ ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. ‘Your Brain On... Autism’ • SEASON 6 • EPISODE 1 LINKS Dr. Ami Klin at Emory University: https://ctsn.emory.edu/faculty/klin-ami.html Dr. Ami Klin at Marcus Autism Center: https://www.marcus.org/about-marcus-autism-center/meet-our-leadership/ami-klin  Dr. Joseph Buxbaum at Mount Sinai: https://profiles.icahn.mssm.edu/joseph-d-buxbaum  Dr. Andrea Love’s website: https://www.immunologic.org/ Dr. Andrea Love on Instagram: https://www.instagram.com/dr.andrealove  REFERENCES Autism Spectrum Disorder: A Review. JAMA, 2023. https://jamanetwork.com/journals/jama/article-abstract/2800182  Is There a Bias Towards Males in the Diagnosis of Autism? A Systematic Review and Meta-Analysis. https://link.springer.com/article/10.1007/s11065-023-09630-2  Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. https://pubmed.ncbi.nlm.nih.gov/38592388/  Eye-Tracking–Based Measurement of Social Visual Engagement Compared With Expert Clinical Diagnosis of Autism. https://jamanetwork.com/journals/jama/fullarticle/2808996  Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. https://www.nature.com/articles/s41588-022-01104-0  Rare coding variation illuminates the allelic architecture, risk genes, cellular expression patterns, and phenotypic context of autism. https://www.medrxiv.org/content/10.1101/2021.12.20.21267194v1  Andrew Wakefield and the fabricated history of the alleged vaccine-autism link. https://geneticliteracyproject.org/2024/04/29/andrew-wakefield-and-the-fabricated-history-of-the-alleged-vaccine-autism-link/ VACCINES & AUTISM 1. Major Cohort Studies Hviid et al., 2019 – Annals of Internal Medicine A nationwide study of 657,461 Danish children found no increased risk of autism in vaccinated children compared to unvaccinated peers — even among those with risk factors such as a sibling with autism. Ann Intern Med. 2019;170(8):513–520 Madsen et al., 2002 – New England Journal of Medicine In 537,303 Danish children, researchers found no difference in autism rates between vaccinated and unvaccinated groups, and no relationship with age, timing, or date of vaccination. NEJM. 2002;347:1477–1482 Jain et al., 2015 – Journal of the American Medical Association (JAMA) A U.S. cohort of 95,727 children — including those with siblings with autism — showed no link between MMR vaccination and autism risk, even in genetically predisposed children. JAMA. 2015;313(15):1534–1540 Madsen et al., 2003 – JAMA A study of 467,450 Danish children found no relationship between thimerosal-containing vaccines and autism. JAMA. 2003;290(13):1763–1766 DeStefano et al., 2022 – Vaccine A retrospective cohort of over 500,000 U.S. children with ASD found no increase in adverse events or worsening of autism-related symptoms following vaccination. Vaccine. 2022;40(16):2391–2398 2. Population-Level Epidemiologic Evidence Taylor et al., 1999 – The Lancet One of the earliest large epidemiological studies found autism prevalence was the same in vaccinated and unvaccinated children, and the age of onset was unrelated to the timing of MMR vaccination. Read: Lancet. 1999;353(9169):2026–2029 Institute of Medicine (U.S.) Immunization Safety Review, 2011 A global review of studies from the U.S., Denmark, Sweden, and the U.K. concluded there is no causal relationship between vaccination status and autism, and no plausible biological mechanism linking vaccines (including thimerosal) to ASD. Read: National Academies Press / PubMed 20669467 3. Systematic Reviews and Meta-Analyses Taylor et al., 2014 – Vaccine A comprehensive meta-analysis of 10 studies including over 1.2 million children found no association between vaccination and autism or ASD. Vaccine. 2014;32(29):3623–3629 Maglione et al., 2014 – Pediatrics Review of 67 high-quality studies covering the full U.S. immunization schedule concluded that vaccines are safe, adverse events are rare, and there is no link to autism, type 1 diabetes, or other chronic conditions. Pediatrics. 2014;134(2):325–337 Parker et al., 2004 – Pediatrics Systematic review of 10 primary studies examining thimerosal exposure found no relationship between vaccines and ASD. Authors noted that studies showing an association were methodologically flawed or biased, while robust studies consistently showed safety. Pediatrics. 2004;113(6):1904–1910 Offit & Hackett, 2003 – Clinical Infectious Diseases Review of immunology and epidemiology concluded that claims that vaccines “overwhelm” or “damage” the immune system are not biologically plausible based on how the immune system actually functions. Clin Infect Dis. 2003;46(9):1450–1456
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  • Your Brain On... Diabetes
    Behind the staggering statistics on global diabetes prevalence are millions of individuals with different stories, struggles, and solutions. In this episode, we explore how diabetes affects your brain, body, and cognition, and how it can be prevented, managed, and (in many cases) reversed. We share some powerful personal stories from the clinic, bust some persistent food myths, and learn why diabetes is as much a neurological emergency as a metabolic one. Plus, we speak to three leading experts who are changing the way we treat diabetes: BRENDA DAVIS, RD: renowned dietitian and global authority on plant-based nutrition. DR. MICHELLE MCMACKEN, MD: Executive Director of Nutrition and Lifestyle Medicine at NYC Health + Hospitals, Associate Professor at NYU, and public health leader. DR. THEODORE FRIEDMAN: Professor and Chair of Internal Medicine at Charles Drew University. In this episode, we discuss: • The difference between Type 1, Type 2, and prediabetes • How diabetes can contribute to cognitive decline • The role of lipotoxicity and intramuscular fat in insulin resistance • Why “cutting carbs” isn’t the full story (and how to focus on food quality) • How public health systems are evolving to make prevention accessible and equitable • The real science behind CGMs (and why glucose spikes shouldn’t cause a panic) • How new drugs like Ozempic can support (but not replace) lifestyle change This is... Your Brain On Diabetes. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.  ‘Your Brain On... Diabetes’ • SEASON 5 • EPISODE 10 [FINALE] Season 6, coming soon! LINKS Brenda Davis’ website: https://brendadavisrd.com/ Dr. McMacken at NYC Health: https://med.nyu.edu/faculty/michelle-mcmacken Dr. Theodore Friedman at CDU: https://www.cdrewu.edu/directory/friedman-md-phd-theodore/
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  • Your Brain On... Alzheimer’s (Mythbusting Special)
    Alzheimer’s disease is constantly surrounded by myths and misinformation. Let’s set the record straight. In this episode, we bust through the most persistent Alzheimer’s myths, with facts based on decades of clinical experience and cutting-edge research. Myths include: • “Alzheimer’s is inevitable in old age” • “It’s all genetic, and there’s nothing you can do” • “There’s no cure, so diagnosis is useless” • “Supplements and vitamins can prevent or cure Alzheimer’s” • “Statins and vaccines cause Alzheimer’s” Plus many others. We also share our science-backed insights and practical tips for helping you prevent cognitive decline, starting TODAY. ‘Your Brain On... Alzheimer’s (Mythbusting Special)’ • SEASON 5 • EPISODE 9 SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/ ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai. CONNECT WITH THE BRAIN DOCS Website: https://thebraindocs.com/ Instagram: https://www.instagram.com/thebraindocs TikTok: https://www.tiktok.com/@thebraindocs
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  • Your Brain On... Purpose (Sherzai Family Special)
    With big changes happening in the Sherzai family household, we sat down for a roundtable discussion about the concept that will shape what we’re all doing next: our purpose. In this ‘unplugged’ mid-season chat, we’re joined by our kids — Sophia and Alex! — for a wide-ranging conversation about our values and goals. How they form, how they falter, and how they evolve, in an increasingly noisy world. Together, we discuss: • The neurological and evolutionary importance of purpose • How a firm sense of purpose can help us develop better habits • The difference between ‘internal’ and ‘external’ purpose • How we can stay focused on our values in the face of modern life’s distractions • The promises and pitfalls of AI in shaping (and potentially hijacking) our sense of purpose Sophia — now heading off to Boston! — works in biomedical engineering and brain-computer interfaces. And Alex (self-proclaimed Tetris champion) is focused on the intersection of brain health and artificial intelligence. This is Your Brain On... Purpose, a Sherzai Family Special!
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  • Your Brain On... Creatine
    Creatine for Alzheimer’s — let’s separate the hype from the hope. A new study has caused a stir in June 2025, but lead researcher Matthew K. Taylor told us: “ I don’t think I can recommend it to a patient that this is going to ultimately have some sort of cognitive influence.” We speak to Dr. Taylor and Dr. Russell Swerdlow in this episode, discussing: • Role of creatine in your brain, and why it matters for energy metabolism • What the 2025 study found (and why it wasn’t designed to prove effectiveness) • How scientific nuance gets lost in supplement hype • Why even promising early data must be handled with care • The vital difference between hype and hope Dr. Russell Swerdlow, MD is Director of the University of Kansas Alzheimer’s Disease Research Center. Dr. Matthew Taylor, PhD, RD is Associate Professor of Dietetics & Nutrition at the University of Kansas Medical Center. This is... Your Brain On Creatine. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On’ is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.  ‘Your Brain On... Creatine’ • SEASON 5 • EPISODE 8 LINKS  Dr. Taylor at the University of Kansas: https://www.kumc.edu/mtaylor3.html Dr. Swerdlow at the University of Kansas: https://www.kumc.edu/rswerdlow.html REFERENCES 1. Smith AN, Choi IY, Lee P, Sullivan DK, Burns JM, Swerdlow RH, Kelly E, Taylor MK. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2025 Apr;11(2):e70101. 2. Taylor MK, Burns JM, Choi IY, et al. Protocol for a single-arm, pilot trial of creatine monohydrate supplementation in patients with Alzheimer’s disease. Pilot Feasibility Study. 2024;10(1):42.  3. Habeck C, Risacher S, Lee GJ, et al. Relationship between baseline brain metabolism measured using [18 F]FDG PET and memory and executive function in prodromal and early Alzheimer’s disease. Brain Imaging Behav. 2012;6(4):568-83.  4. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports. Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18.
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A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life’s everyday health questions and learn the essentials of brain health and optimization, one topic at a time.
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