The Bob Harrington Show

Cardiologist Bob Harrington talks to Mitch Elkind, chief science officer for Brain Health and Stroke at the AHA, about the heart-brain connection and why what's good for the brain is good for the heart.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association  https://www.ahajournals.org/doi/10.1161/CIR.0000000000001078
Migraine Headache: An Under-Appreciated Risk Factor for Cardiovascular Disease in Women https://www.ahajournals.org/doi/10.1161/JAHA.119.014546
Cardiovascular disease patients have increased risk for comorbidity: A cross-sectional study in the Netherlands
https://doi.org/10.1080/13814788.2017.1398318
Characteristics and treatment of midlife-onset epilepsy: A 24-year single-center, retrospective study
https://doi.org/10.1002/epd2.20253
Traumatic Brain Injury and Risk of Neurodegenerative Disorder
https://doi.org/10.1016/j.biopsych.2021.05.025
Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence
https://doi.org/10.3390/ijms222413488
The neuropathological diagnosis of Alzheimer's disease
https://doi.org/10.1186/s13024-019-0333-5
Failed Semaglutide for Early Alzheimer's Not the End of the Road?
https://www.medscape.com/viewarticle/failed-semaglutide-early-alzheimers-not-end-road-2025a1000y4l
Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration
https://doi.org/10.1161/circulationaha.121.055018
Reduced regional cerebral blood flow in patients with heart failure
https://doi.org/10.1002/ejhf.874
Heart-brain Interactions in Heart Failure
https://doi.org/10.15420/cfr.2018.14.2
While You Were Sleeping, the Brain's 'Waste Disposal System' Was at Work
https://www.medscape.com/viewarticle/while-you-were-sleeping-brains-waste-disposal-system-was-2025a1000mbb
Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder
https://doi.org/10.1001/jamapsychiatry.2024.3599
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356
"VOODOO" Death https://ajph.aphapublications.org/doi/full/10.2105/AJPH.92.10.1593
Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome https://doi.org/10.1093/braincomms/fcaf299
Unlocking Longevity: Aging Reimagined  https://www.medscape.com/viewarticle/1002241
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
New ACS Guidelines
2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
https://doi.org/10.1161/CIR.0000000000001309
ACS Guideline Chair and Vice-Chair Discussion
https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l
Antiplatelet/Antithrombotic Strategies
Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI
https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt
Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507980
Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC)
https://www.nejm.org/doi/full/10.1056/NEJMoa2507532
Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis
https://doi.org/10.1016/j.jacadv.2025.102504
Factor XI Inhibitors
Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review
https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu
Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke
OAC-Naive Subgroup From OCEANIC-AF Published
https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz
GLP-1 and Myotrophic Drugs
Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4)
https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1
Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial
https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf
CRISPR and Lipid Lowering
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
https://www.nejm.org/doi/full/10.1056/NEJMoa2504747
Gene Therapy Shows Lipid Improvement but Raises Flags
https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw
Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3
https://www.nejm.org/doi/full/10.1056/NEJMoa2511778
Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV)
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428
Prehospital GLP IIb/IIIa
Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Drs Harrington, Rodriguez, and Ridker discuss the changing field of cardiac prevention, where imaging fits in, and the new concept of standard modifiable risk factor-less patients.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
https://doi.org/10.1161/CIR.0000000000001078
Development and Validation of the American Heart Association's PREVENT Equations
https://doi.org/10.1161/CIRCULATIONAHA.123.067626
C-Reactive Protein and Cardiovascular Risk Among Women With No Standard Modifiable Risk Factors: Evaluating the 'Smurf-Less but Inflamed'
https://doi.org/10.1093/eurheartj/ehaf658
Mortality in STEMI Patients Without Standard Modifiable Risk Factors: A Sex-Disaggregated Analysis of SWEDEHEART Registry Data
https://doi.org/10.1016/S0140-6736(21)00272-5
Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women
https://www.nejm.org/doi/10.1056/NEJMoa2405182
Statins for the 'SMuRFLess But Inflamed': Silent Vascular Inflammation and the Challenge of Translational Science
https://doi.org/10.1016/j.jacbts.2025.101318
VERVE-101: A Promising CRISPR-Based Gene Editing Therapy That Reduces LDL-C and PCSK9 Levels in HeFH Patients
https://academic.oup.com/ehjcvp/article/10/2/89/7492807
You may also like:
Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

Cardiologist and author Eric Topol discusses the science of longevity, why the key to healthy aging is prevention, and the perils of a fixation on reversing ageing.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Super Agers: An Evidence-Based Approach to Longevity
https://www.simonandschuster.com/books/Super-Agers/Eric-Topol/9781668067666
Wellderly study
https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/genomic-medicine/wellderly/
Lotte Bjerre Knudsen
https://erictopol.substack.com/p/lotte-bjerre-knudsen-the-scientist
Organ aging signatures in the plasma proteome track health and disease
https://doi.org/10.1038/s41586-023-
Deep Medicine
https://drerictopol.com/portfolio/deep-medicine/
You may also like:
Hear John Mandrola, MD, give a summary and his perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact [email protected]

The 2021 winner of the Nobel Prize in medicine, Ardem Patapoutian speaks of his love for science, why he wishes he had an MD, and the importance of getting out of the lab to inspire young people.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
Nobel Prize in Physiology or Medicine 2021
https://pubmed.ncbi.nlm.nih.gov/39429349/
https://www.nobelprize.org/prizes/medicine/2021/press-release/
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels https://pubmed.ncbi.nlm.nih.gov/20813920/
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
https://doi.org/10.1126/science.aau6324
PIEZO Ion Channels in Cardiovascular Functions and Diseases
https://doi.org/10.1161/CIRCRESAHA.123.322798
You may also like:
Hear John Mandrola, MD, with his summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
[email protected]