NEJM This Week

This week, we feature new research on transcatheter treatment for tricuspid regurgitation, multicancer early-detection testing, resuscitation strategies for septic shock, and an experimental approach to restoring vision. We review advances in breast cancer treatment, follow a puzzling case of prolonged fever and lymphadenopathy, and report on scientific reproducibility. Perspectives discuss outbreak response, obesity trials, and the enduring value of the medical generalist.

This week, we feature new research on statin therapy in older adults, treatments for IgG4-related disease and advanced breast cancer, and a once-weekly oral regimen for HIV. We review Andes virus and follow a challenging case of a disseminated infection. Articles explore scientific independence, opioid-settlement funds, pharmaceutical policy, and the role of community in patient care.

This week, we feature new research on anticoagulation for atrial fibrillation, treatment for narcolepsy, and gene and cell therapies for multiple myeloma and Wiskott–Aldrich syndrome. We review the clinical use of common genetic variants and follow a case of a young child with fatigue and frequent falls. Perspectives explore access to sickle cell therapies, child health, and biomedical science.

This week, we feature new research on colorectal cancer surveillance, metabolic acidosis in critical illness, pediatric leukemia, and food-allergy prevention. We also review esophageal cancer and follow a case of severe nutritional deficiency and memory loss. Perspectives address AI and the clinical workforce, physician staffing in the Indian Health Service, human trafficking and child health, and the enduring legacy of the HIV epidemic.

This week, we feature new research on gene-edited therapies for children with β-thalassemia and sickle cell disease, treatment for membranous nephropathy, coronary revascularization after myocardial infarction, and an outbreak of severe methemoglobinemia. We review treatment decisions in multiple myeloma, follow a case of man with fever and rash, and report on psychedelic drug development. Perspectives address preventive care, AI-assisted translation, barriers to health care access, and the long shadow of Bedlam.