NEJM This Week

This week, we feature new research on antithrombotic therapy after acute coronary syndrome, treatments for Sjögren’s disease and infective endocarditis, and a new therapy for small-cell lung cancer. We review advances in H. pylori infection, follow a case of vision loss, and report on innovations in hemophilia treatment, clinical research ethics, clinical trial prediction markets, payment models in primary care, Medicaid policy, and trust in medicine.

This week, we feature new research on gene editing for hereditary angioedema, a chemotherapy-free approach to acute lymphoblastic leukemia, and treatments for ulcerative colitis and HIV. We review adult ADHD and follow a challenging case involving a spinal mass. We report on lung cancer screening, and Perspectives explore care interventions for older adults, access to fertility care, and the evolving role of AI in medicine.

This week, we feature new research on transcatheter treatment for tricuspid regurgitation, multicancer early-detection testing, resuscitation strategies for septic shock, and an experimental approach to restoring vision. We review advances in breast cancer treatment, follow a puzzling case of prolonged fever and lymphadenopathy, and report on scientific reproducibility. Perspectives discuss outbreak response, obesity trials, and the enduring value of the medical generalist.

This week, we feature new research on statin therapy in older adults, treatments for IgG4-related disease and advanced breast cancer, and a once-weekly oral regimen for HIV. We review Andes virus and follow a challenging case of a disseminated infection. Articles explore scientific independence, opioid-settlement funds, pharmaceutical policy, and the role of community in patient care.

This week, we feature new research on anticoagulation for atrial fibrillation, treatment for narcolepsy, and gene and cell therapies for multiple myeloma and Wiskott–Aldrich syndrome. We review the clinical use of common genetic variants and follow a case of a young child with fatigue and frequent falls. Perspectives explore access to sickle cell therapies, child health, and biomedical science.