Featuring articles on semaglutide for heart failure in patients with obesity, inhaled fluticasone furoate for treatment of Covid-19, a trial of solanezumab in preclinical Alzheimer’s disease, and targeting the BRAF pathway in pediatric glioma; a review article on the prevention of central line–associated bloodstream infections; a case report of a woman with abdominal distention and acute kidney injury; and Perspective articles on the new USPSTF mammography recommendations, on the ethics of abortion care advocacy, and on reducing the risks of nuclear war.

Featuring articles on ferric carboxymaltose for heart failure with iron deficiency, antibiotic prophylaxis in infants with vesicoureteral reflux, the FGF21 analogue pegozafermin in NASH, and mezigdomide in relapsed and refractory multiple myeloma; a review article on asthma in adults; a case report of a man with a rash; and Perspective articles on a doctrine in name only, on the accelerated approval program for cancer drugs, and on a shared mission.

Featuring articles on the GLP-1 receptor agonist orforglipron for obesity, PCI in older patients with myocardial infarction, DNA editing in T-cell acute lymphoblastic leukemia, and atezolizumab in alveolar soft part sarcoma; a review article on Wilson’s disease; a Clinical Problem-Solving on how it’s all in the timing; and Perspective articles on NIH policy changes regarding international research collaborations, on alleviating medical debt in the United States, and on mass masking without mandates.

Featuring articles on concizumab in hemophilia A or B with inhibitors, the timing of primary surgery for cleft palate, improved mass screening for nasopharyngeal carcinoma, gene editing for sickle cell disease, and on artificial sweeteners; a review article on informative artifacts in AI-assisted health care; a case report of a woman with celiac disease and upper gastrointestinal bleeding; and Perspective articles on Project NextGen, on gerineuropalliative care for patients with dementia, and on sexual and gender minority refugees.

Featuring articles on preventing cardiovascular disease in HIV infection, the effect of hemodiafiltration or hemodialysis on mortality in kidney failure, a new KRAS G12C inhibitor in solid tumors, and on partial artemisinin resistance in malaria parasites; a review article on protein-losing enteropathy; a case report of a girl with abdominal pain and an ovarian mass; and Perspective articles on the Supreme Court and diversity in medicine, on outbreaks in U.S. migrant detention centers, on turning CMS into a health technology assessment organization, and on the clinic that cried safe.