Dr Karan Explores

GLP-1 weight loss drugs are changing medicine, but are we talking about them in the right way? In this episode, Dr Karan Rajan speaks with Dr Federica Amati about GLP-1s, food noise, metabolic health, appetite, gut health, muscle loss, side effects and why nutrition support matters.

Dr Federica Amati explains why these medications should not be seen as simple “weight loss drugs”, how food noise differs from real hunger, and what people should know before, during and after GLP-1 treatment.

📗 Pre-order Dr Federica's book 'The Appetite Reset' here: https://shor.by/fP5H

In this conversation, we cover:

* Why diet remains one of the biggest drivers of chronic disease
* What GLP-1s actually do beyond weight loss
* The difference between homeostatic hunger, hedonic hunger and microbiome-driven hunger
* Why food noise can dominate appetite and eating behaviour
* How protein and resistance training can help protect muscle
* Why micronutrients, fibre and hydration matter on GLP-1s
* The risks of black market or poorly regulated weight loss injections
* How gut health may influence appetite, side effects and long-term success
* Why whole foods and nutrient density still matter most

Chapters
00:00 Preview: GLP-1s, food noise and diet
01:18 Welcome and Dr Federica Amati introduction
02:18 Why GLP-1s need lifestyle and nutrition support
03:21 Diet, chronic disease and preventable deaths
05:08 Who should be using GLP-1 medications?
07:18 Why GLP-1s are metabolic health medications
08:13 GLP-1s, the brain and food noise
08:51 Homeostatic, hedonic and microbiome-driven hunger
09:22 Internal vs external food noise
11:37 Practical ways to reduce food noise
13:40 Loam sponsor read
14:39 Why digestion starts in the brain
17:29 Fullness, stomach stretch and meal replacements
19:47 GLP-1s, muscle loss, protein and resistance training
21:02 Micronutrients, hydration and nutrient density
24:06 Supplements and Mediterranean dietary patterns
26:10 Body image, identity and emotional changes on GLP-1s
28:34 Regulation, TikTok access and black market risks
30:47 Gut microbiome, appetite and natural GLP-1 signalling
42:31 Preparing your gut, managing side effects and final advice

💩 Head to https://loamscience.com/products/loam-prebiotic-fiber-formula?utm_source=youtube&utm_medium=social&utm_campaign=drkaranexplores to try LOAM - and get an additional 10% with code POD10.
💊 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
🚽 Discover Throne's incredible new smart toilet device at http://thronescience.com
📘 For more useful science for your everyday life, grab my best selling book "This Book May Save Your Life": https://geni.us/DrKaranBook
📕 Get my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation
🤖 Discover my digital twin here: http://DrKaran.ai
🧬 Sign up for my Microbiome Course waitlist: https://drkaran.kit.com/microbiome-course-waitlist

About Dr Karan:
Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health.

📱Connect with me:
Instagram: / drkaranrajan
Facebook: / drkaranr
TikTok: / dr.karanr
X: / drkaranrajan
Website: www.drkaranrajan.com

#GLP1 #WeightLossDrugs #FoodNoise #GutHealth #MetabolicHealth

💬 How can you tell if a supplement actually does what it promises to do? There are so many on the market that are underdosed, understudied and not backed up by science. So before you choose your next supplement - this is the data that should inform your decision.
⚡When Dr Karan created LOAM, his aim was to create a fibre supplement backed up by clinically robust data. In this special episode, he outlines the lengthy process that went into making sure it actually delivers results.
🎧 Stay tuned to find out:
➡ What a preclinical study is - and why they are essential
➡︎ How a study can actually show you what’s going on inside someone’s gut
➡︎ Why propionate is so important for gut health - and how LOAM boosts it
➡︎ Why LOAM produces less gas and bloating than other fibre supplements
➡︎ What trials are coming in the future for LOAM  
#DrKaran, #LOAM, #Supplements, #Microbiome, #Butyrate, #GutHealth, #MedicalScience, #HealthEducation, #MythBusting
Don't miss an episode! Subscribe NOW: https://www.youtube.com/@DrKaran?sub_confirmation=1 
📕 Chapters
(0:00) Introduction - How to choose a supplement that works
(0:41) Why preclinical studies are so important
(4:27) The combination that creates gold standard results
(8:14) How the LOAM preclinical study actually worked
(11:44) Surprising results from the LOAM trials
(14:02) The importance of the short-chain fatty acid propionate
(17:43) Why LOAM produces results so quickly 
(20:02) Why supplements don’t impact all people the same
(22:18) How LOAM produces less gas than other fibre supplements
(25:36) Fibre fermentation💩 Head to https://loamscience.com/products/loam-prebiotic-fiber-formula?utm_source=spotify&utm_medium=podcast&utm_campaign=podcast_loam_clinical_trials
🚽 Discover Throne’s incredible new smart toilet device at http://thronescience.com 
🤖 Discover my digital twin here: http://DrKaran.ai 
🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 
📕 Pre-order my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation?utm_source=linktree_profile_share<sid=472cbbde-00e2-42ab-8a3f-725656fab3a5
🎙️ An OG Podcasts production.
About Dr Karan:
Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health.
📱Connect with me:
Instagram: https://www.instagram.com/drkaranrajan/   
Facebook: https://www.facebook.com/DrKaranR/  
TikTok: https://www.tiktok.com/@dr.karanr  
X: https://twitter.com/drkaranrajan  
Website: https://linktr.ee/ThisisVitalInformation

Sleepwalking into arthritis isn’t inevitable. And some changes can show up faster than most people expect.

In this episode, Dr Karan Rajan speaks with Professor Tamiko Katsumoto about why arthritis rates are rising, the differences between rheumatoid arthritis and osteoarthritis, and what the best evidence says about reducing joint inflammation, including a lifestyle medicine intervention where benefits were seen as early as 8 weeks (with the primary endpoint at 16 weeks).

This isn’t about “miracle cures.” It’s about stacking the odds in your favour: Diet quality, fibre, fermented foods, weight and metabolic health, sleep, stress, movement. And how these interact with inflammation, the gut, and joint symptoms.

In this episode, we cover:

∙ RA vs OA: Classic symptom patterns and why they’re treated differently
∙ Why treatments for osteoarthritis can feel limited (and why lifestyle is still worth discussing)
∙ “Food as medicine” and why joints are a symptom you can actually feel change
∙ The “Plants for Joints” study: What changed at 8 weeks and what the 16-week endpoint showed
∙ The gut-joint axis: Gut barrier, microbial diversity, and immune regulation
∙ Why some patients flare on ultra high meat / fibre-free approaches (and what to do instead)
∙ Practical “build my plate” guidance for joint and inflammation support

#Arthritis #JointPain #RheumatoidArthritis #Osteoarthritis #Inflammation

💩 Head to https://loamscience.com/products/loam-prebiotic-fiber-formula?utm_source=youtube&utm_medium=social&utm_campaign=drkaranexplores to try LOAM - and get an additional 10% with code POD10.
💊 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
🚽 Discover Throne's incredible new smart toilet device at http://thronescience.com
📘 For more useful science for your everyday life, grab my best selling book "This Book May Save Your Life": https://geni.us/DrKaranBook
📕 Get my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation
🤖 Discover my digital twin here: http://DrKaran.ai
🧬 Sign up for my Microbiome Course waitlist: https://drkaran.kit.com/microbiome-course-waitlist

About Dr Karan:
Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health.

📱Connect with me:
Instagram: / drkaranrajan
Facebook: / drkaranr
TikTok: / dr.karanr
X: / drkaranrajan
Website: www.drkaranrajan.com

💬 One majorly overlooked part of health is your pelvic floor. You may think it’s just a worry for women - but men need to train their pelvic muscles too. The question is, how?
If you’re the type of person who spends a lot of time sitting all day, have ever experienced gut problems or back pain - or you just want to improve your physique - this one’s for you.
⚡Dr Kelly Peterson is the master of pelvic floor exercises - and shares all her best techniques in this episode.
🎧 Stay tuned to find out:
➡ The 3 types of people who need to work on their pelvic floor
➡︎ What the pelvic floor is actually doing day-to-day
➡︎ The difference between a weak and an overactive pelvic floor
➡︎ Why holding in your pee - and forcing out your poop - are big no-nos
➡︎ The exercises you can do - anywhere! - to strengthen your pelvic floor daily
#DrKaran, #PelvicFloor, #PoopHealth, #GutHealth, #BackPain, #BreathingTechniques, #WomensHealth, #MensHealth, #MedicalScience, #HealthEducation, #MythBusting
Don't miss an episode! Subscribe NOW: https://www.youtube.com/@DrKaran?sub_confirmation=1 
📕 Chapters
(0:00) Introduction
(0:31) How do you train your pelvic floor?
(2:47) What does the pelvic floor actually do day-to-day?
(4:56) Difference between weak and overactive pelvic floor
(9:03) Common pelvic floor problems in men
(12:30) Big no-nos when you go for a poop
(16:14) Breathing techniques to use on the loo
(20:59) Should you worry about making sounds while on the toilet?
(23:02) How to potty train kids and turn them into super poopers
(28:34) Why you shouldn't pee ‘just in case’
(31:05) Tips to improve your pelvic floor - wherever you are
(33:29) How often should we do pelvic floor exercises?
🚽 Discover Throne’s incredible new smart toilet device at http://thronescience.com 
🤖 Discover my digital twin here: http://DrKaran.ai 
🔥  Head to https://loamscience.com/ try LOAM - and get an additional 10% with code POD10.
🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 
📕 Pre-order my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation?utm_source=linktree_profile_share&ltsid=472cbbde-00e2-42ab-8a3f-725656fab3a5
🎙️ An OG Podcasts production.
About Dr Karan:
Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health.
📱Connect with me:
Instagram: https://www.instagram.com/drkaranrajan/   
Facebook: https://www.facebook.com/DrKaranR/  
TikTok: https://www.tiktok.com/@dr.karanr  
X: https://twitter.com/drkaranrajan  
Website: https://linktr.ee/ThisisVitalInformation

Most people can’t name five menopause symptoms beyond hot flushes and the biggest problem might start with the word itself. In this episode, Dr Karan Rajan speaks with Dr Louise Newson, a hormone and menopause specialist, about what’s actually happening biologically, why symptoms get missed or mislabelled, and how evidence, guidelines, and real-world prescribing shape care.
In this conversation, we cover:
Why “menopause” as a label can obscure the underlying hormone biology
The three-hormone framework: Oestrogen, progesterone, testosterone
Why symptoms like brain fog, mood changes, and gut symptoms can be misattributed
Bioidentical vs synthetic hormones (and why molecular structure matters)
Osteoporosis risk, prevention, and what “healthy ageing” should include
Dosing and absorption: Patches vs gels, and why some people need higher doses
Why “guidelines” are a guide and where personalisation matters most
🎬 Chapters
01:22 – Most people can’t name five symptoms beyond hot flushes
01:56 – The definition problem: “A year without a period” doesn’t explain biology
02:59 – Back to basics: oestrogen, progesterone, testosterone
04:24 – Is menopause “just ageing” or a treatable deficiency state?
06:21 – Misdiagnosis: IBS, brain fog, depression and missed hormone deficiency
08:40 – Why “hard to measure” symptoms got ignored in research and guidelines
09:04 – Hormones and inflammation: metabolic risk shifts in perimenopause
10:32 – Osteoporosis risk and prevention: Why this matters clinically
11:22 – Sponsor: Loam
12:14 – Bioidentical vs synthetic hormones: The “key and lock” explanation
14:59 – Contraindications and breast cancer conversations
17:12 – Guidelines vs optimisation: Why safe does not always mean best
18:31 – How to read guidelines: Who wrote them, conflicts, and cited studies
20:18 – Dosing: “lowest effective dose” and why needs vary
22:25 – Louise’s own dosing story: Symptom improvement within days
24:14 – Absorption science: Skin variation and patch placement differences
26:01 – When to consider hormones: Symptoms and quality-of-life impact
27:18 – PMS and PMDD: Severe pre-period symptoms and hormone strategies
28:58 – The timing hypothesis and what WHI got wrong
31:04 – The “stop at 60” myth, synthetic-hormone data, and fear headlines
32:26 – The risks of not taking hormones
34:07 – Sponsor: Throne
35:11 – Gut microbiome and hormones: Reflux, bloating, and symptom shifts
41:29 – Outcomes and personalisation: The metric is quality of life
42:15 – Mental health outcomes discussion and clinic data
💩 Head to https://loamscience.com/products/loam-prebiotic-fiber-formula?utm_source=youtube&utm_medium=social&utm_campaign=drkaranexplores to try LOAM - and get an additional 10% with code POD10.
💊 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe
🚽 Discover Throne's incredible new smart toilet device at http://thronescience.com
📘 For more useful science for your everyday life, grab my best selling book "This Book May Save Your Life": https://geni.us/DrKaranBook
📕 Get my new book, This Is Vital Information, here: https://linktr.ee/ThisisVitalInformation
🤖 Discover my digital twin here: http://DrKaran.ai
🧬 Sign up for my Microbiome Course waitlist: https://drkaran.kit.com/microbiome-course-waitlistAbout Dr Karan:Dr. Karan Rajan is a doctor, author, and educator dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humour. His content provides reliable, research-driven insights designed to inform and empower viewers to better understand their health.📱Connect with me:Instagram: / drkaranrajanFacebook: / drkaranrTikTok: / dr.karanrX: / drkaranrajanWebsite: www.drkaranrajan.com