FYI - For Your Innovation

• Curing Hair Loss With Sean McClain

  In this episode, ARK’s Cathie Wood and Brett Winton sit down with Sean McClain, Founder and CEO of AbSci, to explore how generative AI is reshaping drug discovery, development timelines, and clinical costs. Sean walks through real-world examples of AI-designed antibodies—such as AbSci’s breakthrough HIV antibody and a regenerative treatment for hair loss—and explains how these platforms are helping unlock previously “undruggable” biology.They discuss AbSci’s Phase 2-ready hair growth antibody (BS201), the company’s partnerships with Caltech and AMD, and why the FDA’s evolving embrace of AI could accelerate the end of animal testing. The conversation closes with a forward-looking discussion on the role of regenerative medicine in longevity—and why AI drug discovery might just pull biotech out of its multi-year bear market.Key Points From This Episode:(00:00:00) How AbSci uses generative AI to design antibodies from scratch(00:02:42) HIV, ion channels, and the promise of targeting "undruggable" biology(00:06:28) AbSci’s BS201 drug for hair regrowth: mechanism, speed, and cost advantages(00:13:20) Clinical timeline: From concept to Phase 2 readout in 3.5 years(00:15:34) Bringing costs down: $100–150M vs. the industry average of $2.4B(00:17:36) Why AI enables “keys designed for specific locks” in drug targeting(00:22:58) What AbSci’s models are trained on—and how prompts work in drug inference(00:25:32) The future of clinical testing: AI replacing animal models(00:36:43) Sarcopenia, strength loss, and regenerative approaches to aging(00:48:10) BS201 as a long-acting pulse therapy—and how it compares to transplants

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• OpenAI's $1 Trillion Ambition | The Brainstorm EP 108

  In this episode of The Brainstorm, hosts Nick Grous, Brett Winton, and guests Frank Downing and Jozef Soja dive into OpenAI's ambitious restructuring plan and its implications for a potential $1 trillion IPO. They explore the intricacies of OpenAI's partnership with Microsoft, the challenges of defining artificial general intelligence (AGI), and the strategic moves shaping the future of AI.If you know ARK, then you probably know about our long-term research projections, like estimating where we will be 5-10 years from now! But just because we are long-term investors, doesn’t mean we don’t have strong views and opinions on breaking news. In fact, we discuss and debate this every day. So now we’re sharing some of these internal discussions with you in our new video series, “The Brainstorm”, a co-production from ARK and Public.com. Tune in every week as we react to the latest in innovation. Here and there we’ll be joined by special guests, but ultimately this is our chance to join the conversation and share ARK’s quick takes on what’s going on in tech today.Key Points From This Episode:OpenAI has restructured as a public benefit corporation, with Microsoft holding a 27% stake. The restructuring includes a clause for declaring AGI, requiring independent verification.The company projects significant revenue growth, aiming for a $100 billion run rate by 2027. OpenAI's valuation could compress as it approaches a trillion-dollar IPO.OpenAI's potential IPO is driven by the need for increased compute and capital.The AI market is expected to see multiple large players, not just a single winner.Amazon's chatbot, Rufus, demonstrates successful consumer AI monetization.For more updates on Public.com:Website: https://public.com/YouTube: @publicinvestX: https://twitter.com/public

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• Robotaxi Rollout | The Brainstorm EP 107

  In this episode of The Brainstorm, join Nick Grous, Tasha Keeney, and Brett Winton as they dive into Tesla's latest earnings, the future of Robotaxis, and the challenges of humanoid robots. Explore insights on Tesla's production ramp, AI advancements, and the potential for full autonomy.If you know ARK, then you probably know about our long-term research projections, like estimating where we will be 5-10 years from now! But just because we are long-term investors, doesn’t mean we don’t have strong views and opinions on breaking news. In fact, we discuss and debate this every day. So now we’re sharing some of these internal discussions with you in our new video series, “The Brainstorm”, a co-production from ARK and Public.com. Tune in every week as we react to the latest in innovation. Here and there we’ll be joined by special guests, but ultimately this is our chance to join the conversation and share ARK’s quick takes on what’s going on in tech today.Key Points From This Episode:Tesla's recent earnings call highlighted increased confidence in their Robotaxi service and plans to scale production rapidly.Elon Musk expressed optimism about achieving unsupervised full self-driving capabilities soon, aiming for 3 million vehicles annually within two years.The discussion explored the complexity of humanoid robots, estimating the problem to be 200,000 times more challenging than Robotaxis.Tesla's strategy involves leveraging AI compute power and Robotaxi cash flow to advance humanoid robot development.Regulatory hurdles remain a significant factor in the rollout of full autonomy and Robotaxi services across different states.For more updates on Public.com:Website: https://public.com/YouTube: @publicinvestX: https://twitter.com/public

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• Solana’s Vision For A Decentralized Future With Anatoly Yakovenko

  In this episode, ARK’s Brett Winton and Lorenzo Valente sit down with Anatoly Yakovenko — co-founder of Solana — to explore how Solana is evolving into a high-performance, globally distributed financial infrastructure. Anatoly shares the network’s origin story, explains how Solana leverages parallel compute and hardware innovation to scale, and outlines why execution—not just settlement—is the future of crypto-based finance.The discussion covers how Solana compares to centralized systems like NASDAQ, why monolithic architecture matters, and how innovations like Firedancer and Alpenglow will push the boundaries of decentralized coordination and real-time price discovery. They also explore tokenomics, validator incentives, and why Solana is built to handle machine-generated transaction volumes at global scale.Anatoly offers a wide-ranging perspective on decentralization, future throughput limits, and why blockchains should eventually become invisible to end users.Key Points From This Episode:00:00:00 Why Solana exists00:06:25 Time as a cryptographic primitive: Solving blockchain inefficiency with Time-Division Multiple Access (TDMA)00:11:33 Why Proof of History may disappear — and what replaces it.00:14:16 How cryptographic guarantees could replace 100 years of financial regulation.00:20:03 Settlement vs. execution: Why all the value accrues at the execution layer.00:26:29 Handling millions of transactions per second — and how Solana filters noise.00:38:47 Solana vs. NASDAQ: Building a global atomic state machine for finance.00:42:25 Validator incentives, staking yields, and real vs. inflationary revenue.00:48:46 Firedancer, Alpenglow, and multiple concurrent proposers: What’s next for Solana.00:54:52 Is quantum computing a real crypto threat? Anatoly’s timeline and optimism.

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• SpaceX And… The Louvre? | The Brainstorm EP 106

  In this episode of the Brainstorm podcast, Sam Korus, Brett Winton, and Nick Grous dive into the latest advancements in space exploration with SpaceX's groundbreaking achievements and the evolving landscape of gene sequencing technology. From the successful Starship test flight to the economic implications of reusable rockets, and the cost dynamics of long-read versus short-read sequencing, this discussion offers a deep dive into the future of technology and innovation.If you know ARK, then you probably know about our long-term research projections, like estimating where we will be 5-10 years from now! But just because we are long-term investors, doesn’t mean we don’t have strong views and opinions on breaking news. In fact, we discuss and debate this every day. So now we’re sharing some of these internal discussions with you in our new video series, “The Brainstorm”, a co-production from ARK and Public.com. Tune in every week as we react to the latest in innovation. Here and there we’ll be joined by special guests, but ultimately this is our chance to join the conversation and share ARK’s quick takes on what’s going on in tech today.Key Points From This Episode:SpaceX's Starship test flight was a major success, showcasing the potential for reusable rockets.The 31st reuse of a booster marks a significant milestone in reducing space travel costs.Starlink's technology provides superior video quality and data collection during launches.Long-read sequencing is becoming more affordable, opening new research opportunities.The prediction market is experiencing rapid growth, with significant shifts in market share.Apple's investment in F1 broadcast rights highlights the growing interest in motorsports.For more updates on Public.com:Website: https://public.com/YouTube: @publicinvestX: https://twitter.com/public

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