CrowdScience

Tuberculosis kills more than a million people every year. It’s the world’s leading cause of death from a single infectious agent. This is despite the fact that we've had a cure for TB since the 1940s and a vaccine that’s over 100 years old. So why is TB still causing so many people to die?
That’s what CrowdScience listener John in Tanzania wants to know, and presenter Marnie Chesterton is on the case. Over in Paris, she’s joined by Dr Claas Kirchhelle, historian of science, medicine and technology at French National Institute of Health and Medical Research (INSERM) to look into the history and efficacy of the vaccine, known as BCG.
As Dr Maximiliano Gutierrez, Associate Research Director at the Francis Crick Institute adds, the BCG is both effective and ineffective, protecting children well against severe TB, but offering inconsistent and often poor protection in adults. He also explains that antibiotics are a trickier treatment than we might expect. Over in Kenya’s Kibera slums, Janet tells us her about her experience of the drugs first hand.
Dr Dany Beste, Senior Lecturer In Microbial Metabolism, University of Surrey, has been described as a dietician of mycobacterium tuberculosis. She explains the limitations of our knowledge of this bacterium, and why it is proving such a tricky customer.
And since a better vaccine is the main hope for reducing the TB burden, Professor Angelique Luabeya Kany Kany, Chief Research Officer at University of Cape Town, shares her hopes for the first new alternative vaccine in 100 years: m72. Large phase 3 clinical trials are currently underway, and, if successful, could prevent millions of cases, and deaths a year.
Presenter: Marnie Chesterton
Producer: Marnie Chesterton
Editor: Ben Motley
(Photo: Doctor with vial of the doses vaccine for BCG Bacillus Calmette Guerin against tuberculosis disease. Medicine and health care concept - stock photo - Credit: angelp via Getty Images)

Stare up at the night sky, and if you’re lucky, you might see a shooting star. Some people might make a wish, but CrowdScience listener Scott in California in the USA, thinks differently. He’s wondering how dangerous they might be.

Shooting stars are actually meteors, ending their incredible journey whizzing through the depths of space by burning through our atmosphere, and crashing down to earth. And Scott’s not wrong to worry about them! In May 2026, an enormous meteor exploded off the coast of Massachusetts, causing a loud sonic boom before crashing into the ocean, releasing the equivalent energy of 300 tons of TNT!

So, should we be worried? Marnie Chesterton is on the case.

In Australia, Hadrien Devillepoix is the chief scientist for the Desert Fireball Network, which tracks meteors through the sky, and tries to recover any meteorites which make it to earth. He explains just how many of these smaller space rocks arrive on our planet every day, how many of them survive long enough to make it to the surface, and tries to figure out how much should we be worried about it happening to us.

Over in the USA, NASA are less worried about the meteors, and more concerned about their big brothers – asteroids. These are the ones which could take out your whole neighbourhood. Or your whole city. Or even the whole planet. Kelly Fast, with NASA's Planetary Defense Coordination Office explains what the chances are one might be headed our way, and what we could do about it if they are. Push them away, pull them off course, or blow them up, are the options on the table.

But space rocks, small OR large, aren’t the only things which could be tumbling down on our heads from outside our atmosphere. In fact, you might be more likely to be hit but something of our own – a man-made piece of space junk, falling out of orbit and whizzing towards the surface. Stephen Wokes, chief engineer at Astroscale, explains their mission: to use their innovative satellite to clean up Low Earth Orbit, and reduce the risk to us here on the ground.

PRESENTER: Marnie Chesterton
PRODUCER: Emily Knight
PRODUCTION COORDINATOR: Stuart Laws
EDITOR: Ben Motley
(photo: Meteor Impact On Earth - Fired Asteroid In Collision With Planet - Contain 3d Rendering - elements of this image furnished by NASA - stock photo- Credit: RomoloTavani via Getty Images)

We’re delving into the CrowdScience archive to give you another chance to hear an award-winning show from 2025.
CrowdScience listener Dorit has a problem. She wants the tiles in her new bathroom to be arranged randomly but, no matter what she does, it still looks like they form some kind of pattern.
This has got Dorit thinking about randomness – what is it, how do you create it, why do we find it so hard to recognise, and is anything really random at all? And if nothing is truly random, does it mean that everything is theoretically predictable? Tiling your bathroom is a much more existential problem than you might have thought.
Never afraid of a question, whether big (is everything pre-determined?) or small (how do I tile my bathroom?), CrowdScience is on the case.
Anand Jagatia heads to Switzerland to meet Hugo Duminil-Copin, a mathematician at the University of Geneva who specialises in probability theory. On the top floor of an old bank, Hugo has Anand flipping an imaginary coin in a random order. Hugo explains that randomness is something that cannot be predicted by any means – so why is it so easy for Hugo to guess what Anand’s next move is?
Meanwhile, at the National Institutes of Mental Health in Maryland USA, Susan Wardle is a cognitive neuroscientist who researches how the human brain processes visual information. Can neuroscience help Dorit with her tiling problem, and is there a reason why the human brain likes to put random objects into some kind of order?
Geneva is also the birthplace of the first Quantum Random Number Generator for smartphones, and CrowdScience has persuaded some of the University of Geneva’s finest quantum physicists to hook a photon detector up to a synthesiser. Thanks to Tiff Brydges and Nicolas Brunner, we can actually hear quantum particles behaving randomly. But is quantum randomness truly random, or just a pattern that we can’t see? And could quantum physics help Dorit tile her bathroom?
Presenter: Anand Jagatia
Producer: Ben Motley
Editor: Cathy Edwards
(Photo: Many wooden dice - stock photo- Credit: akiyoko via Getty Images)

Space missions are searching for evidence of extra-terrestrial life. CrowdScience listener George in Kenya wants to know what could be up there, and if there’s a risk it could harm humanity.
With rovers currently analysing samples on Mars, missions searching for the building blocks of life on Jupiter’s icy moons, George’s concern that there could be diseases in space is timely. Presenter Anand Jagatia sets out to try and find an answer while keeping his feet on the Earth.
He meets astrobiologist Dr Michaela Musilova, who runs experiments to try and understand what kinds of microbes could survive on other planets. In her work at NASA’s Jet Propulsion Laboratory, she recreates Mars-like environments that test lifeforms’ resilience to the rigours of the Red Planet.
And if there are harmful pathogens in space, how do we make sure these missions don't bring them back to Earth? Anand talks to ‘planetary protection officer’ Silvio Sinibaldi from the European Space Agency, who explains what experts are doing to protect us. He helps Anand get suited and booted in specialist clothing so they can enter a highly sterile environment called a ‘clean room’, where things being sent to space are built.
He also meets Paul Meacham, former chief engineer on the Rosalind Franklin Rover. The rover is being sent to Mars to try to determine whether life ever existed there, and even whether it still does.
Paul shows us around the Airbus Defence and Space site where his team built the rover and explains high-tech measures to avoid contamination.
And what would a programme on space be without an astronaut? Anand meets Kate Rubins, who spent 300 days on the International Space Station. While she was there, she ran experiments investigating what happens to microbes in space. It turns out that microbes affect humans differently in orbit to how they affect us on Earth.
Presenter: Anand Jagatia
Producer: Tom Bonnett
Editor: Ben Motley
(Photo : 3D render of the Coronavirus Covid-19 floating in the air with astronaut wearing space suit. - stock photo- Credit: Artur Debat via Getty Images)

CrowdScience listener Liana from Canada got in touch to ask about some very specific rocks she’d seen on an island in Indonesia – jagged, rugged and a very strange shape: hexagonal. They were in long columns, and clicked together like a jigsaw. But what are they, and how did they get there?
Across the world in the UK, CrowdScience listener Sarah emailed us to ask about the famous rocks of the Giant’s Causeway in Northern Ireland. What makes them so uniformly hexagonal?
Presenter Alex Lathbridge investigates, visiting the Giant’s Causeway to speak to geologist Dr Kirstin Lemon from the Geological Survey of Northern Ireland. She explains how this amazing landscape formed, and why the mythical rocks look the way they do today.
We also hear from Dr Alfend Rudyawan from Institut Teknologi Bandung in Indonesia about Liana’s intriguing rocks. Are these distant locations more closely related than you might think?
And we look to nature – because angular, uniform hexagons crop up surprisingly often. Professor Jean-Marc Schlenker from the University of Luxembourg explains why hexagons are much better than other shapes.
Presenter: Alex Lathbridge
Producer: Hannah Fisher
Editor: Ben Motley
(photo: Giant`s Causeway in Northern Ireland Stock photo- Credit: MANUEL FIL ORDIERES GARCIA via Getty Images)