PodcastsEducaciónThe Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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1484 episodios

  • The Human Upgrade: Biohacking for Longevity & Performance

    How I Finally FIXED My Terrible Sleep After 18 Years : 1428

    08/03/2026 | 9 min
    Block toxic light with these glasses: https://truedark.com/discount/DAVETUBE

    Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it.

    Thank you to our sponsors!
    -Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap
    -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Chapters:
    0:00 – Introduction
    0:38 – The Real Reason You're Still Tired
    0:59 – How Light Controls Your Sleep Quality
    1:36 – Circadian Rhythm Explained (NASA-Approved)
    2:51 – The Secret Sleep Trigger
    5:29 – Blue Light: The Silent Sleep Killer
    6:12 – How to Hack Your Evening Light
    7:52 – Screen Time vs. Sleep Time
    8:12 – Social Jet Lag: The Weekend Mistake

    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427

    06/03/2026 | 11 min
    This week’s stories:

    Healthy Diets That Offset "Bad Genes"
    A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol.
    • Sources:
    -https://www.science.org/doi/10.1126/sciadv.ads7559
    -https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179
    -https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity

    Micro-Habits in Sleep, Activity, and Diet That Extend Life
    Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation.
    • Sources:
    -https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424
    -https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502
    -https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life

    Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure
    New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too
    • Sources:
    -https://elifesciences.org/reviewed-preprints/108825v2
    -https://www.nature.com/articles/s42255-025-01297-8
    -https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review

    Tyrosine and Lifespan: What the Data Says for Men
    A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically
    • Sources:
    -https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx
    -https://www.eurekalert.org/news-releases/1105915
    -https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men

    War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator
    Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking.
    • Sources:
    -https://www.sciencedaily.com/releases/2024/07/240718124709.htm
    -https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds
    -https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers
    -https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387

    All source links are provided for direct access to the original reporting and research.

    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.

    New episodes every Tuesday, Thursday, Friday, and Sunday.

    Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026

    Thank you to our sponsors!
    -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.
    -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    0:00 - Introduction
    0:18 - Story #1: Diet vs. Genetics
    2:14 - Story #2: 1% Better Every Day
    4:26 - Story #3: Sulfur Amino Acids & Fat Loss
    5:55 - Story #4: Tyrosine & Longevity
    7:58 - Story #5: Doomscrolling & Aging
    10:00 - Weekly Roundup
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426

    05/03/2026 | 56 min
    Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
    -Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout

    Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging.

    Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization.

    This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.

    You'll Learn:
    Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline
    How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat
    The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events
    Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics
    How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox
    Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like
    How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging
    The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox
    Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine

    Thank you to our sponsors!
    The One Device | Use code DAVE for $10 off at http://theonedevice.com/dave
    HeartMath | Go to https://www.heartmath.com/dave to save 15% off.
    Igniton | Go to Igniton.com and use code DAVE to save 15% off.
    Puori | Go to http://Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding

    Resources:
    • Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Introduction
    03:00 – Microplastics in the Brain
    08:40 – Olyxir Tea Strip Solution
    10:10 – Health Impacts & Weight Gain
    11:05 – Environmental Solutions
    14:29 – The Teabag Problem
    18:57 – How to Remove Microplastics
    22:04 – Olive Leaf Benefits
    28:26 – Josephine's Scientific Background
    33:00 – Guarana & Lymphatic Support
    34:22 – Skincare & Microplastics
    36:38 – Sauna Protocol
    44:19 – Household Exposure Sources
    47:18 – Workout Clothing Risk
    48:59 – Leather vs Synthetic Fashion
    50:54 – Pregnancy & Fertility
    54:20 – Closing & Discount Code
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Why Are Hackers Microdosing “Sex Drugs” Now? : 1425

    03/03/2026 | 53 min
    Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice.

    Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise.

    This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.

    You'll Learn:
    Why precision medicine outperforms population-based health strategies for human performance
    How to layer genomics, transcriptomics, and proteomics into one complete biological picture
    Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine
    How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits
    The real story on metformin, peptides, and which supplements actually move the needle
    How AI can help you understand your own biology and act on it faster
    Why biohacking precision beats random stacking every time

    Thank you to our sponsors!
    • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order.
    • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com
    • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.
    • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs

    Resources:
    • Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:53 – Intro to Precision Medicine
    01:58 – Dr. Bajnath's Holistic Health Journey
    05:03 – Pharmaceuticals vs. Supplements
    07:58 – Peptides and Longevity Molecules
    10:34 – Sexual Health and Vitality
    13:56 – Vascular Health and Blood Flow
    15:14 – Multi-Omics Approach
    19:03 – DNA and Genomics
    22:17 – Transcriptomics and RNA
    24:24 – Proteomics and Inflammation Markers
    32:00 – The Human Exposome
    34:55 – Key Health Biomarkers
    36:58 – Cell Membrane Dynamics
    40:28 – Biological Investment Strategy
    41:53 – Life Extension Possibilities
    48:52 – Bioenergetics and Mitochondria
    49:47 – Quantum Medicine and the Future
    51:33 – Vagal Nerve Stimulation
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424

    01/03/2026 | 14 min
    What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?

    Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

    The twist? You can activate it in just 10 minutes a day, no prescription required.

    Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...

    Thank you to our sponsors!
    -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.
    -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    0:00 – Introduction
    0:46 – Lobsters and Human Longevity Connection
    1:14 – Understanding Telomeres and Aging
    2:26 – How Lobsters Defy Aging
    3:32 – Rethinking Aging Biology
    4:53 – The Telomerase Challenge
    6:43 – Natural Ways to Protect Telomeres
    9:33 – Meditation's Role in Anti-Aging
    11:04 – Different Meditation Techniques
    13:19 – Benefits and Long-Term Effects
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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