The Human Upgrade: Biohacking for Longevity & Performance

Use Dave10 at calocurb.com to get a discount

How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting Easier

Host Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower.

The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer. Originally investigated through a multimillion-dollar research program, this bitter plant extract activates specialized receptors in the digestive tract that stimulate the body's natural appetite-regulating hormones. Sarah explains how this discovery led to Calocurb, a supplement designed to reduce hunger, control cravings, and make fasting and calorie restriction easier.

Dave and Sarah break down the biology of GLP-1, CCK, PYY, ghrelin, and leptin, exploring how these hormones influence hunger, fullness, food cravings, and metabolic health. Unlike injectable GLP-1 medications such as Ozempic and Wegovy, Amarasate works through bitter taste receptors in the gut to stimulate the body's own satiety signaling. They examine why the timing and location of these signals matter, how quickly the extract begins working, and what distinguishes this approach from conventional appetite suppressants.

Sarah shares findings from four human clinical trials, including research reporting an average 18% reduction in calorie intake following consumption of the hops extract. They discuss how activating gut receptors can influence eating behavior, why some people struggle with persistent hunger despite consuming enough calories, and how manipulating the body's natural fullness signals could change approaches to weight management.

The discussion also examines a six-month randomized, placebo-controlled study involving approximately 150 participants, which reported an average 5.5% reduction in body weight, with estimated fat loss and no detected average muscle loss. Sarah describes findings suggesting approximately 3.5 times greater visceral fat reduction compared with placebo, raising questions about whether targeted appetite regulation could support healthier body composition. Dave and Sarah explore why preserving lean muscle while reducing abdominal fat is especially important for metabolic health, healthy aging, and longevity.

They also explore how hops extract may make intermittent fasting and extended fasting easier by reducing hunger and food cravings. Dave discusses the practical challenges of fasting, while Sarah explains how bitter receptor activation can help people manage appetite without constantly fighting the urge to eat. They examine the potential applications for time-restricted eating, longer fasting windows, calorie control, and sustainable weight management.

Finally, Dave and Sarah challenge conventional assumptions about willpower, hunger, and obesity, exploring why overeating is not simply a failure of discipline. They discuss the relationship between gut-brain signaling, metabolic hormones, food intake, and the emerging science of naturally regulating appetite, including how plant-derived compounds could complement nutrition, exercise, and other metabolic health strategies.

This episode is essential listening for anyone interested in natural appetite suppression, hops extract, intermittent fasting, GLP-1, hunger hormones, weight loss, visceral fat, muscle preservation, metabolic health, gut-brain signaling, and science-backed strategies for controlling cravings and eating less.

You'll Learn:
How a patented compound extracted from hops activates bitter receptors in the gut to stimulate GLP-1, CCK, and PYY, the hormones involved in hunger and fullness
Why clinical research found that hops extract reduced calorie intake by approximately 18%, and what that means for appetite control and overeating
How a six-month clinical trial reported 5.5% body-weight loss, reduced visceral fat, and no detected average muscle loss
Why hunger, cravings, and overeating involve complex hormonal signaling rather than simply a lack of willpower
How natural appetite regulation may make intermittent fasting, extended fasting, and calorie restriction easier to maintain
How hops-derived compounds differ from injectable GLP-1 medications, and what the research suggests about their potential role in weight management

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Sarah Kennedy, Sarah Kennedy Calocurb, Dave Asprey, The Human Upgrade, Calocurb, Amarasate, hops extract, hops weight loss, hops appetite suppressant, natural appetite suppressant, natural hunger suppressant, stop overeating, reduce hunger, control cravings, food cravings, hunger control, weight loss, fat loss, visceral fat reduction, belly fat, muscle preservation, lean muscle mass, GLP-1, natural GLP-1, GLP-1 activation, GLP-1 alternatives, Ozempic, Wegovy, CCK, cholecystokinin, PYY, peptide YY, ghrelin, leptin, hunger hormones, satiety hormones, bitter taste receptors, gut-brain axis, gut-brain signaling, intermittent fasting, fasting without hunger, extended fasting, time-restricted eating, fasting made simple, calorie restriction, calorie intake reduction, metabolic health, obesity, weight management, body composition, fat loss without muscle loss, biohacking, longevity, natural weight loss supplements

Resources:
• Calocurb | Use Dave10 at calocurb.com to get a discount
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)


Thank you to our sponsors!
- Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Mars Men | For a limited time, our listeners get 50% off FOR LIFE, Free Shipping, AND 3 Free Gifts at Mars Men at Mengotomars.com.
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off

Timestamps:
00:00 - Trailer
01:32 - Intro
03:06 - Discovering Hops Extract
07:58 - Finding the Right Hop
10:15 - Clinical Trial Results
15:34 - No Rebound Weight Gain
19:47 - Personal Story & Fasting
23:05 - Women's Fasting Study
29:32 - Willpower & Hunger
38:42 - Combining With GLP-1s
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Explore House of Evolution: https://daveasprey.com/house-of-evolution/

Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two Governors General of Canada, to explore experimental gene therapy, biological age reversal, stem cell re-education, immune rejuvenation, muscle growth, and the emerging science of extending human lifespan.

Recorded in the Amazon rainforest in Ecuador, the conversation explores three advanced longevity treatments Dave and Tim are working with through House of Evolution, their venture focused on expanding access to experimental therapies. They discuss how these technologies work, the early results they're observing, and why some treatments are currently available outside the United States.

Dave reveals that after undergoing a two-day stem cell re-education treatment, blood testing approximately two months later indicated his immune system was 15.2 years younger. Tim explains how the procedure uses signaling molecules from umbilical cord blood stem cells to influence a patient's own immune cells before returning them to the body. They explore the potential implications for chronic inflammation, autoimmune conditions, and age-related immune dysfunction.

The discussion turns to follistatin gene therapy, an experimental treatment designed to increase a protein involved in muscle growth and maintenance. Dave and Tim share preliminary results, including a reported average nine-year reduction in biological-age measurements, increased lean muscle mass, and reductions in body fat. They examine why preserving muscle and reducing visceral fat may be critical for longevity, particularly as anabolic resistance and sarcopenia become more common with age.

They also explore klotho gene therapy, which targets a longevity-associated protein involved in kidney function, cognitive health, and aging. Tim describes early observations of substantially increased klotho levels following treatment, while Dave explains why this protein has become a major focus of his longevity research. The conversation also examines plasmid-based gene delivery, how it differs from directly editing human DNA, and the unanswered questions surrounding long-term safety and effectiveness.

Dave and Tim challenge conventional thinking about healthspan, lifespan, and longevity escape velocity, discussing whether emerging treatments could eventually help people maintain youthful physical and cognitive function for decades longer. They examine how advanced biomarker testing and predictive models are being used to track biological aging and estimate changes in life expectancy.

Finally, they look ahead to stem cell banking, genetic reprogramming, and regenerative medicine, including the possibility of rejuvenating a person's own cells and growing replacement tissues. They also address the high costs, limited availability, and regulatory challenges surrounding these technologies, emphasizing that many of the results discussed remain preliminary rather than clinically established evidence of age reversal.

This episode is essential listening for anyone interested in biological age reversal, gene therapy, follistatin, klotho, stem cell re-education, immune rejuvenation, autoimmune disease, muscle growth, visceral fat, regenerative medicine, longevity escape velocity, and the future of anti-aging medicine.

You'll Learn:
How Dave's two-day stem cell re-education treatment was followed by a reported 15.2-year reduction in his measured immune age, and how the procedure works
Why follistatin gene therapy is being investigated for muscle growth, sarcopenia, body composition, and biological aging
How experimental plasmid-based gene therapies increase protein production without intentionally editing the human genome
What early klotho gene therapy results suggest about protein levels, cognitive performance, kidney health, and longevity
Why immune system aging, chronic inflammation, and visceral fat may contribute to age-related disease and physical decline
How stem cell banking, cellular reprogramming, and regenerative medicine could shape the future of longevity treatments

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. Tim Cook, Tim Cook longevity doctor, Dave Asprey, The Human Upgrade, House of Evolution, anti-aging treatments, reverse aging, biological age reversal, biological age testing, immune age, immune system rejuvenation, stem cell re-education, stem cell therapy, umbilical cord blood stem cells, immune cell reprogramming, autoimmune disease, chronic inflammation, inflammaging, gene therapy, follistatin gene therapy, follistatin, klotho gene therapy, klotho protein, minicircle gene therapy, plasmid DNA, MiniCircle, muscle growth, muscle loss, sarcopenia, anabolic resistance, lean muscle mass, body fat reduction, visceral fat, regenerative medicine, stem cell banking, genetic reprogramming, longevity medicine, longevity escape velocity, lifespan extension, healthspan, biological aging, experimental longevity treatments, biohacking, human longevity

Resources:
• The House of Evolution is A members-only longevity community combining gene expression therapy, stem cell therapy, and small-group experiences in destinations around the world. Apply here https://daveasprey.com/house-of-evolution/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
- Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.
- OneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE.
- MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE.

Timestamps:
00:00 — Trailer
00:59 — Follistatin Gene Therapy
05:25 — How Plasmids Work
09:30 — Longevity Escape Velocity
16:30 — Follistatin Results & Data
21:30 — Klotho: The Cognitive Protein
24:30 — House of Evolution
30:30 — Stem Cell Re-Education
39:00 — Stem Cell Banking
41:30 — The Future of Longevity
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for $5/day, where every single thing on it has to be validated in humans, not mice. I could not spend the five dollars. In this video I'll show you the entire list and the two most powerful things I found… which cost nothing at all.

You'll Learn:
How to build a science-backed longevity routine for less than $5 a day
Why omega-3s, GlyNAC, and magnesium may help slow aging and support cellular repair
How creatine, vitamin D, and L-theanine support brain health, muscle function, and focus
Why blackout curtains, red light, and blue-light-blocking glasses can improve sleep and circadian health
How walking, morning sunlight, fiber, and quality sleep can improve longevity without expensive supplements
What Dave learned from spending $2.5 million on biohacking and why preventing damage is cheaper than repairing it

Timestamps:
00:00 — The $5/Day Challenge
02:50 — Omega-3s: Aging Clock
04:24 — GlyNAC: Master Antioxidant
06:06 — Magnesium for Sleep
07:50 — Creatine: Brain and Muscle
09:39 — Vitamin D and Theanine
12:09 — Light: Curtains and Bulbs
15:52 — Free: Walking, Sun, Fiber
19:00 — The Full Cost Summary
20:09 — Why I Spent Millions

Thank you to our sponsors!
-Echo | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.
-MyVitalC | Visit www.myvitalc.com/davesfav to unlock Dave’s discount
-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestorelaser.com/DAVE

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
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We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare.
Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.
In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple).
We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats.

Timestamps:
00:00 — Intro
02:01 — The Big 4 Metabolic Impairments
08:21 — The Dangers of Oxalates
12:02 — The Fifth Disruptor: Histamine
16:22 — Becoming Your Own Body Interpreter
28:41 — How Do We Get Off Oxalates?
35:41 — Dave’s Recipe for Releasing Oxalates
44:40 — Hacks for Histamines
50:32 — Amyloid 101: What You Should Know
56:56 — Should You Beware of B6?
59:54 — What’s the Best Kind of Protein?

Thank you to our sponsors!
-Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.
-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
-Neuronic | Go to www.neuronic.online Code DAVE for $100 off
-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE irestorelaser.com/DAVE

Resources
Website: tericochrane.com
Instagram: @tericochranebeyondnutrition
YouTube: @TeriCochrane
The Global Sustainable Health Institute: globalsustainablehealthinstitute.com
Read: The Wildatarian Diet by Teri Cochrane
What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

Danger Coffee: https://dangercoffee.com/discount/dave15?
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Join my Substack: https://substack.daveasprey.com
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler

Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality.

Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance, working with elite athletes, military personnel, and high-performing professionals to understand how people can reliably access flow states.

Dave and Steven begin by exploring the neuroscience of flow and why it may be one of the most powerful altered states available without drugs. Steven explains how dopamine, norepinephrine, serotonin, anandamide, and endorphins contribute to the flow experience, why his research suggests caffeine can increase flow susceptibility, and how chasing the neurochemical high of peak performance can become dangerous.

They discuss the darker side of flow training, including its potential risks for people prone to mania, the importance of recovery, and why attempting to remain in a flow state indefinitely can undermine performance. Steven shares how his training programs approach sleep, attention, and behavioral changes to help people access flow more consistently.

The conversation then moves into psychedelics, ketamine-assisted therapy, and the neuroscience of trauma. Steven introduces emerging research suggesting that unresolved emotional patterns may involve the brain's predictive processing systems. Dave shares a personal experience involving Joe Rogan and how revisiting an early childhood memory changed his emotional response to public criticism.

Dave and Steven also explore how the brain constructs reality, including the neuroscience of perception, sensory processing, and the flexible boundary between ourselves and our environment. They discuss how flow alters our sense of self, why the brain predicts what we experience before we consciously perceive it, and how these mechanisms may help explain certain spiritual and out-of-body experiences.

Finally, Steven reveals new research investigating the neurological connections between flow, intuition, synchronicity, and purpose. He discusses emerging theories of consciousness, the role of information processing in subjective experience, and how artificial intelligence may change the future of human performance.

You'll Learn:
How flow states influence dopamine, norepinephrine, serotonin, anandamide, and endorphins, and why Steven's research suggests caffeine may help make the brain more susceptible to flow.
Why chasing the neurochemical high of flow can become dangerous, how flow training may affect people prone to mania, and why sleep and recovery are essential for sustained peak performance.
How ketamine-assisted therapy may help uncover forgotten emotional experiences and why Steven believes the brain's predictive processing systems play an important role in trauma.
How the brain constructs our perception of reality, why sensory information reaches consciousness at different speeds, and what happens to our sense of self during altered states.
Why flow may enhance intuition and how emerging neuroscience research is investigating connections between synchronicity, purpose, and the brain's information-processing systems.
How Steven is using neuroscience, artificial intelligence, and years of flow training data to develop more accessible methods for improving focus, learning, and performance.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Steven Kotler, Dave Asprey, flow state, neuroscience of flow, peak performance, Flow Research Collective, dopamine, caffeine and flow, altered states, consciousness, psychedelics, ketamine therapy, trauma, predictive processing, neuroplasticity, intuition, synchronicity, brain science, mental performance, cognitive enhancement, flow triggers, serotonin, anandamide, meditation, human optimization, artificial intelligence, We Are as Gods, The Art of Impossible

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Resources:
• Explore Steven Kotler's books, research, and flow training programs at https://www.flowresearchcollective.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!
ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save
OneSkin | For a limited time try the new OS-01 FACE RICH CREAM with 15% off at oneskin.co/DAVE
Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

Timestamps:
00:00 — Trailer
01:12 — Intro
05:08 — Psychedelics and Peak Performance
11:10 — Trance, Voices, and Shamanism
18:00 — Dangers of Flow Training
24:00 — Ketamine and Innate Intelligence
30:00 — The Prediction Problem
35:25 — Embodied Cognition
46:30 — Consciousness and Synchronicity
50:20 — New Books and Research
53:00 — Flow for the Many
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.