The Human Upgrade: Biohacking for Longevity & Performance

Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.

Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose

Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer.

Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health.

Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging.

The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair.

Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging.

They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light.

The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science.

They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized.

This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare.

You’ll Learn:
Why wrinkles may be a downstream sign of deeper cellular aging
How skin metabolic age can be assessed using metabolomics and multiple biological markers
What methylene blue may do inside mitochondria and why it pairs with red light
How NAD+ precursors, spermidine, copper peptides, SOD, and ergothioneine may support skin biology
Why platelet-derived “Vampire Exosomes” are being studied for cellular signaling, repair, and senescence
How red light therapy interacts with mitochondrial function, oxidative stress, and DNA repair
Why some traditional acids and surface-level skincare strategies may not address long-term skin function
How proteomics and AI could change the way skincare is measured and personalized
What Dave and the Young Goose team use to support skin during travel and other high-stress environments

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity

Resources:
• Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!
- Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off
- Timeline | Go to timeline.com/dave and get up to 20% off when you subscribe and save
- Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

Timestamps:
00:00 — Trailer
01:09 — Skin Testing & Metabolomics
04:48 — Longevity Skincare Paradigm
07:50 — Airplane Skincare Routine
11:15 — Tardigrade Juice & Antioxidants
16:00 — Mitochondrial Dysfunction
21:00 — Skincare Ingredients: Old vs New
27:20 — Vampire Exosomes
32:30 — Red Light Therapy Stacking
38:00 — Proteomics & Klotho
41:00 — Exosome Safety, Growth Factors & MicroRNAs
44:00 — Senescent Cells & Senomorphics
47:00 — Skin Longevity Takeaways
50:00 — Outro
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.

Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity.

Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis.

Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver.

The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process.

Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation.

This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking.

You’ll Learn:

Why fatty liver can develop even in people who are thin or rarely drink alcohol
Why normal bloodwork may not always reveal what is happening inside the liver
How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function
What rapid weight loss and GLP-1 use may mean for liver function
How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health
Why liver scans, nutrition, and supplement quality may matter for long-term health

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking

Resources:
• Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
- MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com.

Timestamps:
00:00 — Trailer
01:00 — Liver Basics & Signs
05:30 — Liver Scan Technology
08:15 — Chemicals & Liver Disease
11:30 — Deliverance Formula Story
17:15 — Estrogen, Alcohol & HRT
22:30 — GLP-1s & Liver Toxicity
28:00 — Bile & Gut Health
33:10 — Chimerism & Transplants
41:30 — Hormesis & Painkillers
50:00 — Sweeteners, Hormones & Thyroid
55:00 — Outro - Discount
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.com
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This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction.

If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off.

You'll Learn:
Why protein burns 20–30% of its own calories just to digest — and how that "thermic effect" makes it the most powerful diet lever for cutting visceral fat
Why short, intense workouts (as little as 10–20 minutes a week) beat long cardio sessions for triggering fat-burning hormones
How cold exposure activates brown fat to burn visceral fat as fuel, and why consistency matters more than intensity
Why resistance training is one of the most effective tools for long-term fat loss, not just muscle-building
How poor sleep tanks growth hormone by up to 70% a night and drives up cortisol, both of which directly promote visceral fat storage
Why chronic stress is the single biggest driver of visceral fat, and how it creates a self-reinforcing loop that resists diet and exercise alone

Thank you to our sponsors!
Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Timestamps:
00:00 — Introduction & Calorie Myth
01:27 — Power of Protein
02:37 — Cut Sugar & Carbs
03:48 — HIIT for Fat Loss
05:44 — Cold Exposure
06:32 — Resistance Training
08:22 — Sleep & Growth Hormone
10:30 — Stress & Cortisol
13:39 — Breaking the Fat Loop

Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
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The Human Upgrade Podcast: https://www.instagram.com/
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Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
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Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion
Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness.
Sources:
https://www.bloomberg.com/news/articles/2026-09-22/ozempic-maker-novo-looks-to-target-hair-loss-in-consumer-push
https://www.novonordisk.com/investors/capital-markets-day-2026.html
https://www.irishexaminer.com/business/companies/arid-41914219.html
~~~

Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency
A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth.
Sources:
https://doi.org/10.1177/21532176261486979
https://www.sciencedaily.com/releases/2026/09/260923035926.htm
https://pharmaceutical-journal.com/article/news/children-taking-glp-1s-can-be-at-risk-of-nutritional-deficiencies-study-finds
~~~

Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health
Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites.
Sources:
https://www.nature.com/articles/s44220-025-00468-6
https://health.au.dk/en/display/artikel/the-stomachs-brain-is-more-in-sync-with-the-mind-during-mental-distress
https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html
~~~

Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk
A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods.
Sources:
https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203
https://link.springer.com/article/10.1186/s12916-026-05132-z
https://www.escardio.org/news/press/press-releases/common-food-preservatives-linked-to-high-blood-pressure-and-heart-disease/
~~~

Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats
A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives.
Sources:
https://www.nature.com/articles/s41598-017-05051-3
https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/

This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026

Thank you to our sponsors!
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
- iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 — Intro
00:18 — Novo Nordisk & Hair Loss
02:52 — GLP-1s & Kids' Nutrition
05:08 — Stomach-Brain Sync
07:49 — Preservatives & Heart Risk
10:53 — Taurine & Stress Resilience
13:28 — Outro
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.
Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study:
Social connections are really good for you. Loneliness kills.
It’s the quality of your close relationships that matters.
Good close relationships don’t just protect your body, they protect your brain.

Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:
how relationships improve your physical, mental and emotional health. (More than you know!)
how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)
what social fitness is and how to practice it. (Yes, it’s a flex.)
ways to enliven and energize your relationships. (Energy totally matters.)
why casual and work relationships matter more than you think. (A surprisingly big contribution.)

You'll Learn:
Why loneliness physically harms your body — affecting your brain, immune function, sleep, and pain sensitivity
The likely mechanism behind why relationships improve health: how a good listener helps regulate your stress response
What "social fitness" is and why relationships wither from neglect, even without conflict
The four attachment styles and why knowing yours matters before committing to a relationship
Why intergenerational friendships may be one of the most underused tools for personal growth and happiness

Resources:
• Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it.
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Timestamps:
00:00 — Introduction & the Study
04:43 — What Makes a Good Life
08:47 — How Relationships Heal
13:44 — Happiness: Nature vs Nurture
17:59 — Measuring Happiness
23:56 — Life Stages & Happiness
35:34 — Social Fitness
44:30 — Energizing Relationships
56:14 — Attachment & Childhood
1:05:04 — Casual Friends & Legacy

Thank you to our sponsors!
- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.
- Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.

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