The Human Upgrade: Biohacking for Longevity & Performance

Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads

Your nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you the exact framework for building real nervous system mastery instead of running on autopilot until it fails.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Jonny Miller, host of the Inner Frontier Podcast and founder of Nervous System Mastery, who has taught more than 1,000 people how to build the skills of interoception, self-regulation, and emotional fluidity. A former Silicon Valley founder turned nervous system expert, Jonny brings a rare mix of rational, data-driven thinking and deep somatic work to a field most high performers avoid entirely.

They break down why interoception, self-regulation, and emotional fluidity are the three learnable skills behind every major shift in performance, relationships, and decision-making, and why most high achievers have spent their whole lives disconnected from what's happening below the neck. Jonny introduces the half-life of reactivity, his framework for measuring how quickly someone can move from triggered back to calm, and explains how free diving became his gateway into surrender, breath work, and pressure equalization as a form of high-stakes meditation. Dave shares his own parallel journey through nervous system work, including lessons from running 40 Years of Zen and a costly business betrayal that reshaped how he reads people. Dave and Jonny also open up about grief, including Jonny's experience losing his fiancée and later his mother, and how community and co-regulation shape how fast someone actually heals.

You'll Learn:
Why interoception, self-regulation, and emotional fluidity are the three core skills behind nervous system mastery
What the half-life of reactivity is and how to use it to measure real emotional progress
How free diving works as a form of high-stakes meditation and a direct feedback loop for unclenching
Why congruence between your inner and outer state matters more than staying composed under pressure
How team intuition can be used as a practical filter in high-stakes hiring decisions
Why co-regulation with friends and community can dramatically shorten the grieving process
What Jonny's Breath Buddy device is designed to teach kids and families about nervous system regulation

Thank you to our sponsors!
- MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
- Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Jonny Miller, Inner Frontier Podcast, Nervous System Mastery, interoception, self-regulation, emotional fluidity, half-life of reactivity, free diving, breathwork, nervous system regulation, somatic healing, grief processing, co-regulation, congruence, trauma response, boundary setting, narcissism, hiring intuition, cold plunge, surrender, NSDR, yoga nidra, Breath Buddy, biohacking, high performance, 40 Years of Zen, psychedelic integration, Silicon Valley founder, emotional resilience

Resources:
• Nervous System Mastery Course: https://www.nsmastery.com/
• Listen To Jonny’s Podcast ‘The Inner Frontier’ at: https://open.spotify.com/show/1lGD5wIfhnE4bepja42C9S
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:10 – Losing His Fiancée
04:28 – Nervous System Mastery
11:52 – Community & Co-Regulation
17:37 – From Head to Body
22:52 – Surrender & Free Diving
28:54 – Half-Life of Reactivity
35:33 – Congruence & the $100M Lesson
38:58 – Stupidity, Narcissism & Intuition
50:22 – Biohacking Trojan Horses
59:11 – Breath Buddy & Outro
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Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial Intelligence

Your brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to use artificial intelligence as a tool for brain optimization instead of a crutch that erodes your memory, focus, and critical thinking.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Jim Kwik, one of the world's leading experts in memory improvement, brain optimization, and accelerated learning. For more than 30 years, Jim has served as the brain coach to professional athletes, political leaders, business magnates, and Hollywood icons, with corporate clients including Google, Nike, SpaceX, and Harvard. He hosts the Kwik Brain podcast with over 100 million downloads, reaches 200,000 people annually through live keynotes, and just wrapped his 14th annual Beyond Biohacking Conference with 5,000 attendees in Austin. Jim overcame a childhood brain injury that left him labeled "learning disabled," and turned that struggle into a mission he calls "no brain left behind."

They break down the MIT study showing that people who use AI to write and think score worse on memory and comprehension than those who rely on their own brains, and why that matters for anyone serious about longevity, human performance, and anti-aging. Jim introduces the concept of digital dementia and cognitive sovereignty, explaining how nootropics, neuroplasticity, and functional medicine can support your biology while AI still requires you to keep your own hardware sharp. They cover the MEDS Rx framework for brain optimization: meditation, exercise, diet, sleep optimization, and relationships, plus why mitochondria, metabolism, and inflammation from processed food directly impact your cognitive output. Jim also shares how his own kids use AI as a tutor rather than a replacement for thinking, and why sleep inertia and the first few minutes after waking set the tone for your entire day.

This is essential listening for anyone serious about biohacking, hacking their own brain, longevity, neuroplasticity, brain optimization, supplements, and building a Smarter Not Harder approach to human performance in the age of AI.

You'll Learn:
Why the MIT study found AI users had weaker memory and comprehension than people who did the work themselves
What digital dementia and digital deduction are, and how they quietly erode your cognitive muscles
How to use AI as an augmented intelligence partner instead of a replacement for critical thinking
The MEDS Rx framework for brain optimization: meditation, exercise, diet, sleep, and relationships
Why the first few minutes after waking determine your focus and mood for the entire day
How spaced repetition and AI-assisted learning can lock in new skills and behavior change faster
The HUMAN framework for staying irreplaceable in a world run by algorithms

Thank you to our sponsors!
- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
- Neuronic | Go to www.neuronic.online Code DAVE for $100 off
- Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide.
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Jim Kwik, Limitless, Kwik Brain, digital dementia, cognitive sovereignty, human intelligence, artificial intelligence, MIT AI study, brain injury recovery, accelerated learning, memory improvement, speed reading, neuroplasticity, spaced repetition, memory palace, MEDS Rx framework, sleep inertia, attentional priming, metacognition, digital deduction, brain optimization, cognitive flexibility, cognitive anti-fragility, 40 Years of Zen, biohacking, Beyond Biohacking Conference, HUMAN framework, learning how to learn, GPS dependency, mental fatigue, burnout recovery, Limitless Daily

Resources:
• Learn More About Jim At: https://limitlessdaily.com/
• Follow Jim On Instagram At: https://www.instagram.com/jimkwik/
• Watch Jim On YouTube At: https://www.youtube.com/jimkwik
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:55 – Intro
06:54 – AI as Tool, Not Crutch
13:00 – Protecting Cognitive Sovereignty
21:28 – Digital Dementia Explained
27:13 – AI-Enhanced Learning Techniques
32:18 – Speed Listening and Reading
40:38 – Rapid Tips by Age
46:59 – Building an AI Second Brain
53:04 – Burnout and Brain Optimization
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Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey

Most people see the physical decline of aging as an inevitable process that can only be managed with medications, but this video cuts through that assumption by explaining that the smartest minds in science, including multiple Nobel Prize winners, have identified a single root cause of aging tied to a specific molecule called NAD+.

You'll also learn:
Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog
How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy
The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from
What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/

Thank you to our sponsors!
ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.
Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:
00:00 – The Aging Molecule
01:03 – The War Within Your Cells
03:28 – Builder vs. Demolition Crew
04:34 – NAD+ and Brain Function
06:00 – Root Cause Over Symptoms
08:31 – Fixing the Imbalance
10:10 – Fasting for NAD+
11:30 – The REHIT Protocol
12:37 – The Supplementation Step

Connect with Dave Asprey!
Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles.
Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels.
I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode.
Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you.

Thank you to our sponsors!
-Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Sri Sri Ravi Shankar, Dave Asprey, Art of Living, Sudarshan Kriya, breathwork, pranayama, meditation, non-dual consciousness, gut feeling intuition, biohacking, quantum physics consciousness, Nobel Prize physics, curiosity and childlike wonder, skepticism vs cynicism, scientific temper, dogmatism, veterans PTSD breathwork, SKY campus happiness program, violence prevention, community building, dating apps romance, Elon Musk Mars, computer chip brain implant, duality and consciousness, equanimity, ego and inner voice, spirituality and science, yoga philosophy, guru interview, positive energy radiation, transcending fear

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 - Trailer
01:11 - Curiosity & Skepticism
03:42 - Reality, Physics & Illusion
06:34 - Non-Dual Consciousness
08:37 - Origins of Breathwork
13:36 - Trusting Your Gut Feeling
14:28 - Violence, Peace & Veterans
19:54 - Romance & Dating Apps
23:44 - Science Behind Meditation
27:27 - Fear of the Unknown
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload

Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous?

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel computing hardware for AI applications. Previously a Staff Scientist at Los Alamos National Lab, Coles led their near-term quantum computing group and made significant contributions to quantum computing theory. He holds a Ph.D. in Chemical Engineering from UC Berkeley and a Master of Philosophy in Biochemistry from Cambridge, and he's currently developing a new theory for cancer and chronic disease, the subject of this conversation. His rare combination of hard physics and deep biochemistry gives him a radically different lens on one of medicine's most misunderstood diseases.

Coles lays out his Toxin Sequestration Theory, a framework that reframes cancer tumors not as malignant accidents but as intentional storage vaults the body builds to sequester toxins, heavy metals, seed oils, mold, and excess glucose, away from healthy tissue and mitochondria. He and Dave connect the dots between this theory and chronic disease, biohacking fundamentals, and why chemotherapy itself behaves as a toxin that can backfire. They dig into oxalates, deuterium, linoleic acid, circadian biology, and the detox protocols that support the body's natural ability to shrink these toxic reservoirs.

This conversation challenges the mainstream genetic theory of cancer, explores the metabolic theory popularized by Thomas Seyfried, and lands on a radical, functional medicine-aligned framework for anyone serious about longevity, anti-aging, and human performance. Dave and Coles also break down how sleep optimization, fasting, ketosis, and a carnivore approach to nutrition support the body's detox hierarchy, from fat tissue and the liver to moles, cysts, and eventually tumors themselves.

This is essential listening for anyone serious about biohacking, functional medicine, mitochondria health, brain optimization, nootropics, and taking full control of their metabolism and longevity.

You'll Learn:
Why toxins may be the root cause of Alzheimer's, Parkinson's, autism, and most chronic disease
How Toxin Sequestration Theory reinterprets tumors as the body's backup detox organs
Why chemotherapy ranks among the most tissue-damaging toxins, and what happens when a tumor bursts
The role of oxalates, deuterium, heavy metals, and seed oils in cancer cell hoarding
Why moles, cysts, lipomas, and nodules may be minor versions of the same detox response
How circadian rhythm, sleep, and light exposure affect the body's toxin excretion cycles
What spontaneous tumor regression reveals about lowering your toxic burden
Why tracking tumor progression matters no matter which treatment path you choose

Thank you to our sponsors!

- Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.

- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.

- Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.

- Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: toxin sequestration theory, cancer theory, Patrick Coles, quantum computing scientist, thermodynamic computing, Normal Computing, Los Alamos National Lab, chemotherapy toxicity, oxalates cancer, deuterium toxin, Stephanie Seneff, heavy metal detox, mycotoxins tumors, seed oils cancer, linoleic acid, oleic acid oxidation, lipid peroxidation, glucose toxicity, mitochondria downregulation, genetic theory of cancer, metabolic theory of cancer, Thomas Seyfried, spontaneous tumor regression, backup detox organ, circadian rhythm cancer, mold toxins, forever chemicals, microplastics, bile flow, activated charcoal binders, cholestyramine

Resources:
• Follow Patrick’s Work At: https://www.instagram.com/patrickc_tst/
• Watch Gabby’s Podcast At: https://www.youtube.com/@GabbyReece
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:58 – Introducing Patrick Coles
04:08 – Toxin Sequestration Theory
06:26 – Defining a Toxin
14:13 – Cancer as Backup Detox Organ
15:01 – History of the Theory
16:30 – Deuterium and Oxalates
21:31 – Cancer Theories Compared
28:06 – Chemotherapy and Toxic Overload
37:23 – Tiered Toxin Storage System
45:17 – Diet, Light, and Circadian Rhythm
50:39 – Detox Protocols and Binders
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.