Infectious Disease Puscast

On episode #105 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/9 – 4/22/26.
Host: Daniel Griffin and Sarah Dong
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Links for this episode
Viral
Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients (NEJM)
Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir (NEJM)
Paxlovid doesn't reduce hospitalization, death rates in vaccinated high-risk COVID outpatients, trial shows (CIDRAP)
Risk of Guillain–Barré Syndrome after Laboratory-Confirmed Dengue Infection (NEJM)
A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage (JID)
First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients (JID)
Bacterial
Tetanus Surveillance — United States, 2009–2023 (CDC: MMWR)
Notes from the Field: Tetanus in Four Children — Idaho, Minnesota, Missouri, and Wisconsin, 2024 (CDC: MMWR)
Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults (JAMA)
Efficacy and safety of vancomycin versus 13 alternatives in MRSA-confirmed skin and soft tissue infections: a meta-analysis of 39 randomized controlled trials (Infection)
Methicillin-Resistant Staph Aureus (MRSA) Nasal Swab Utilization as a Predictor for MRSA Skin & Soft Tissue Infections: A Systematic Review and Meta-analysis (OFID)
Practice variation, outcomes and definitions of suppressive antimicrobial therapy for prosthetic joint infections: a systematic review and expert consensus statement (CIC)
Efficacy and safety of VPM1002 and Immuvacin preventing tuberculosis: phase 3 randomised clinical trial (PreVenTB trial) (BMJ)
Comparison of Ceftolozane-Tazobactam and Ceftazidime-Avibactam in the Treatment of Multidrug-Resistant/Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections: A Systematic Review and Meta-analysis (CID)
Do C-Reactive Protein Measurements Predict Treatment Failure in Native Vertebral Osteomyelitis? (OFID)
Fungal
The Last of US Season 2 (YouTube)
Rising burden of severe pediatric coccidioidomycosis: a 25-year single-center study (Journal of the Pediatric Infectious Diseases Society)
Candida glabrata emerges as the most common cause of candidemia: analysis of a large hospital-based database, United States, 2016–2024 (CID)
Test Performance and Clinical Utility of the cobas® eplex Blood Culture Identification Fungal Pathogen Panel (OFID)
Cutaneous Paraconiothyrium cyclothyrioides Infection in Lung Transplant Recipient, Georgia, USA (Emerging Infectious Diseases)
Azole Resistance in Aspergillus fumigatus From Diverse Environments in Ohio, United States, Is Primarily Driven by TR34/L98H and TR46/Y121F/T289A Environmental Signatures (OFID)
Parasitic
Fatal Donor-Derived Disseminated Acanthamoeba Infection in a Liver Transplant Recipient (OFID)
Miscellaneous
Host–microbiome archetypes differentiate infection from pathogen carriage in the human lower airway (Nature Communications)
Music is by Ronald Jenkees
Information on this podcast should not be considered as medical advice.

On episode #104 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/26 – 4/8/26.
Host: Daniel Griffin and Sarah Dong
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode
Viral
Risk of Multiple Sclerosis Among Persons With Epstein-Barr Virus–Positive Mononucleosis (Neurology)
Bacterial
Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study (CID)
Inhaled Antibiotics to Treat Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis (Critical Care Medicine)
ATS/IDSA 2016 Clinical Practice Guidelines for the Management of Adults With Hospital-Acquired and Ventilator-Associated Pneumonia (ISDA)
Risk of Invasive Meningococcal Disease in Children Aged American Society of Breast Surgeons, Society of Breast Imaging, and College of American Pathology 2025 Guidelines for the Management of Infectious and Inflammatory Lesions of the Breast (JAMA Surgery)
Tularemia Antimicrobial Treatment and Prophylaxis: CDC Recommendations for Naturally Acquired Infections and Bioterrorism Response — United States, 2025 (CDC: MMWR)
Effectiveness of Doxycycline in Combination With Other Antibiotics for Gram-Positive Periprosthetic Joint Infections: A Causal Inference Study (OFID)
Reply to Dissent: Guidelines for Management of Community-Acquired Pneumonia (CID)
VancObituary: A summary of a life well lived and a death well timed (Journal of the Pediatric Infectious Diseases Society)
Reports of My Demise Have Been Greatly Exaggerated (Journal of the Pediatric Infectious Diseases Society)
Fungal
The Last of US Season 2 (YouTube)
Parasitic
Red Blood Cell Exchange Transfusion for Severe Babesiosis (JAMA Internal Medicine)
Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply (CID)
Artesunate Treatment of Severe Malaria in Nonendemic Countries: When, Where, How, and What Now? (CID)
Attention for Compliance: Visual Media in Second World War Anti-Malaria Efforts (AJTMH: American Journal of Tropical Medicine and Hygiene)
Screening and Reactivation of Chagas Disease Among Solid Organ Transplant Candidates and Recipients: A 10-Year Single Center Experience in Florida (Transplant Infectious Disease)
Miscellaneous
Phage Therapy in people with Cystic Fibrosis: a systematic review (Internation Journal of Infectious Diseases)
Inverse Probability of Treatment Weighting (Google)
Outcomes associated with empiric azithromycin use among patients hospitalized with non-severe community-acquired pneumonia: emulation of a target trial (CID)
eConsult in infectious diseases: A narrative review (International Journal of Infectious Diseases)
Music is by Ronald Jenkees
Information on this podcast should not be considered as medical advice.

On episode #103 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 3/12 – 3/25/26.
Host: Daniel Griffin and Sarah Dong
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Links for this episode
Viral
Probable Japanese Encephalitis Virus Transmission through Organ Transplantation (NEJM)
Clinical Characteristics and Severity of Rhinovirus/Enterovirus–Associated Hospitalizations: A Multi-country Analysis from the Global Influenza Hospital Surveillance Network, 2017–2024 (OFID)
Bacterial
Eagle effect (Wikipedia)
THE RATE OF BACTERICIDAL ACTION OF PENICILLIN IN VITRO AS A FUNCTION OF ITS CONCENTRATION, AND ITS PARADOXICALLY REDUCED ACTIVITY AT HIGH CONCENTRATIONS AGAINST CERTAIN ORGANISMS (JEM)
Linezolid versus clindamycin for toxin inhibition in severe skin and soft tissue infections: a systematic review and meta-analysis (Infection)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 (Critical Care Medicine)
Caring for Adult Patients With Sepsis (JAMA)
Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 (Intensive Care Medicine)
Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 (Pediatric Critical Care Medicine)
Caring for Pediatric Patients With Sepsis (JAMA)
ACEP Will Not Endorse New Sepsis Guidelines from the Surviving Sepsis Campaign (American College of Emergency Physicians)
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With SepsisThe BLING III Randomized Clinical Trial (JAMA)
Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis (Nature Communications)
Survival trends in patients with difficult-to-treat, antibiotic-resistant, Gram-negative infections in the era of next-generation antibiotics in the USA: a retrospective cohort study (LANCET: Infectious Diseases)
Fungal
The Last of US Season 2 (YouTube)
Empirical Antifungal Treatment of Critically Ⅲ Patients With Influenza-Associated Acute Respiratory Distress Syndrome: A Propensity Score Weighted Observational Study (CID)
Clinical and Radiological Predictors of Invasive Fungal Sinusitis (OFID)
Blood Cultures Contain Populations of Genetically Diverse Candida albicans Strains that May Differ in Echinocandin Tolerance and Fitness (JID)
Can fluconazole be used to treat non-resistant Candida (Candidozyma) auris infections? Preclinical PK/PD data from a Galleria mellonella infection model (JID)
Parasitic
Na-GST-1 adsorbed on Alhydrogel co-administered with different Toll-like receptor agonists in hookworm-naive adults using a controlled human infection model in the USA: a phase 2, double-blind, randomised controlled trial (LANCET: Infectious Diseases)
Miscellaneous
Bridging the Gap: A Needs Assessment of Resources and Support for International Medical Graduates Navigating Visa-Related Career Decisions in Infectious Diseases (OFID)
Number Needed to Treat (NEJM)
Music is by Ronald Jenkees
Information on this podcast should not be considered as medical advice.

On episode #102 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 2/26 – 3/11/26.
Host: Daniel Griffin and Sarah Dong
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of Puscast!
Links for this episode
Viral
Measles Outbreak — New Mexico, 2025 (CDC: MMWR)
Epidemiology of HMPV and Other Respiratory Viral Infections Among Outpatients, 2016–2022 (OFID)
Notes from the Field: Congenital Rubella Syndrome — Florida, 2025 (CDC: MMWR)
Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine (Nature Medicine)
Bacterial
Clinical Outcomes in Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Infection: A Cohort Study (JID)
Duration of therapy for Pseudomonas aeruginosa bacteremia – a post hoc subgroup analysis from the BALANCE randomized controlled trial (CID)
Diagnostic Yield of Tongue Swab- Compared to Sputum-Based Molecular Testing for Tuberculosis in Four High-Burden Countries (CID)
WHO recommends near point-of-care tests, tongue swabs, and sputum poolingfor TB diagnosis (WHO)
Respiratory virus co-infection is a risk factor for adverse outcomes during Staphylococcus aureus bacteraemia (OFID)
Balance Versus Bias: Correcting Misinformation About the 2025 ATS Community-Acquired Pneumonia Guidelines (CID)
Fungal
The Last of US Season 2 (YouTube)
Immunomodulation in the Treatment of Disseminated Coccidioidomycosis (CID)
Parasitic
Comparison of six weeks doxycycline versus six weeks rifampicin or three weeks of the combination of doxycycline plus rifampicin in the treatment of onchocerciasis: a randomized, placebo-controlled, double-blind, phase 2 trial (OFID)
Cutaneous Larva Migrans Within the United States Military Health System – Clinical Presentation and Association with Autochthonous Spread or International Travel (OFID)
Miscellaneous
Distinct prophage infections in colorectal cancer-associated Bacteroides fragilis (Communications Medicine)
Rounding Styles on Inpatient Infectious Disease Consult Services: Impact on Education and Patient-Care Delivery (OFID)
Possible quality indicators for clinical infectious diseases consultations – results from a hybrid Delphi-nominal group approach and scenario study (CMI: Clinical Microbiology and Infections)
Music is by Ronald Jenkees
Information on this podcast should not be considered as medical advice.

On episode #101 of the Infectious Disease Puscast, Daniel reviews the infectious disease literature for the weeks of 2/12 – 2/25/26.
Host: Daniel Griffin and Sarah Dong
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of Puscast!
Links for this episode
Viral
Impact of Proviral-DNA M184V/I on 96-Week Outcomes of DTG/3TC Maintenance Therapy: Results From the VOLVER Clinical Trial (CID)
Tecovirimat for the Treatment of Mpox (NEJM)
Bacterial
Multicounty Outbreak of Salmonella Agbeni Linked to Ice in a Cooler at a County Fair — Illinois, August 2024 (CDC: MMWR)
Legionella Pneumonia in the Modern Era: Clinical Features and Predictors of Mortality (CID)
Cefalexin use in UK acute pyelonephritis practice: unaddressed challenges in dosing, breakpoints and clinical evidence (Journal of Antimicrobial Chemotherapy)
Is three really what we need? Relative effectiveness of benzathine penicillin G and doxycycline treatment regimens for late or unknown duration syphilis in 6 United States jurisdictions, 2016–2021 (CID)
Show Me the "Mino:" In Vitro Efficacy of Minocycline on Clinical Gram-Negative Bacterial Isolates (Microbial Drug Resistance)
Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection
(JAMA Network)
Microbial Flora in War Wounds from the Ukrainian Front Line (NEJM)
Fungal
The Last of US Season 2 (YouTube)
Epidemiology of Aspergillosis Diagnoses in U.S. Adults using a National EHR Database, 2013-2023 (OFID)
Parasitic
State-of-the-Art Review: Chagas Disease—an Enduring Challenge (CID)
Autochthonous Rat Lungworm Angiostrongylus cantonensis Infections in Accidental and Definitive Hosts, San Diego, California, USA (Emerging Infectious Diseases)
Miscellaneous
Ancient bacteria strain discovered in ice cave is resistant to some modern antibiotics(CNN)
First genome sequence and functional profiling of Psychrobacter SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activities (Frontiers in Microbiology)
Music is by Ronald Jenkees
Information on this podcast should not be considered as medical advice.