Immune

The Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Sakaguchi lab paper on FoxP3 and regulatory T cells (Science 2003) Brunkow and Ramsdell description of scurfy mouse mutation (Nature 2001) Nobel Prize writeup on Treg discoveries Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Susan Schwab talks about how she got the research bug, bugs she ate, and her research on how the lipid S1P helps T cells decide- should I stay or should I go. Host: Cindy Leifer Guest: Susan Schwab Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Schwab lab website Monocytes produce the lipid S1P to regulate T cell movement Review on S1P and immune cell migration Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Immune discusses cross-reactive antibodies to avian influenza neuraminidases and a role for gut-derived T cells in the brain to regulate eating behavior.   Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Antibody cross-reactivity to influenza H5N1 (Cell Host Microbe, 2025) Gut-derived T cells regulate behavior (Nature, 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Kristian Andersen from Scripps Research Institute joins Cindy to talk about how he got interested in virus evolution, how the immune system drives viral adaptation, and what we can learn from this research to better prepare us for the next pandemic. Host: Cindy Leifer Guest: Kristian Andersen Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Andersen Lab website Perspective on Immunological drivers of virus emergence Kristian's appearance on TWiV 774 Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.

Cindy and Steph discuss a paper that challenges the textbook dogma that B cells must first bind to an antigen for antibody affinity maturation to occur, and a snippet on dysfunctional T cells during bacterial vaginosis. Hosts: Cindy Leifer and Steph Langel Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Somatic hypermutation in non-specific B cells (Immunity 2025) Dysfunctional T cells during bacterial vaginosis (J Clin Invest 2025) Time stamps by Jolene Ramsey. Thanks! Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected] Information on this podcast should not be construed as medical advice.