The Bottom Line

• The Decisions That Made Me: Harry Destecroix (Ziylo, Science Creates, SCVC)

  Harry Destecroix was studying for his PhD at Bristol University when he co-founded Ziylo. Based on 20 years of Bristol chemistry research, the spin-out company created a new technology that can be developed to treat diabetes more effectively. It's a breakthrough that led to its acquisition by pharmaceutical firm, Novo Nordisk, in a deal reportedly worth up to 600 million pounds. Harry has also founded the incubator, Science Creates and is the founding managing partner of SCVC, a venture capital firm. Harry tells Evan Davis why his own experience of spinning out a company has made him passionate to help other early-stage companies in the Bristol area – whether that’s providing lab space, finance or advice.(Image: Harry Destecroix Credit: Peter Schiazza, Copyright: Science Creates)

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• The Decisions That Made Me: Sophie Mirman

  Sophie Mirman was thrown in at the deep end when – at the age of 13 – she was in a car accident with her parents. They were both badly injured and, a few years later, Sophie felt she had to find a way to help the family finances. She started as a very junior secretary in M&S, applied for jobs she says she wasn’t qualified for, and went on to hold the top jobs at Tie Rack, SockShop and Trotters. She discusses the all-consuming nature of expanding outside the UK and how her more cautious approach these days is, ultimately, more enjoyable. Producer: Sally Abrahams Editor: Matt Willis Sound: Jackie Margerum Production co-ordinator: Katie Morrison(Image: Sophie Mirman. Credit: Pylewell)

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• The Decisions That Made Me: Jesper Brodin (IKEA)

  When Jesper Brodin landed a job as IKEA’s purchase manager in Pakistan, he was only 26. And had no idea he was the only applicant. He’s now spent 30 years with the iconic Swedish brand - since 2017, as CEO of Ingka Group, which runs most IKEA stores. During that time, he’s led two major transformations - taking the company digital and making it more eco-friendly. Now, as he steps down from his role, he tells Evan Davis about the lessons he learned from IKEA’s legendary founder, Ingvar Kamprad. And why he’s planning to buy himself a new guitar.(Image: Jesper Brodin. Credit: JOEL SAGET/AFP via Getty Images)

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• The Decisions That Made Me: Heather Vernon (Woburn Partners)

  Heather Vernon never expected to become an entrepreneur. Her goal after university was to become a teacher, through the Teach First graduate programme - two years of intense learning on the job, schooling disadvantaged children in low income communities. It taught her resilience and prompted a move into politics, initially at a local level, then a job with the Labour party, advising members of the then shadow cabinet. She tells Evan Davis why working at Westminster was initially terrifying and what encouraged her to set up a PR business with a friend. (Image: Heather Vernon Credit: Woburn Partners)

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• Hypotheticals: How Would You React If You Were Boss?

  Three business leaders tackle fictional dilemmas that test their instincts, experience and nerves. To make it more realistic, none of the guests have any idea what the scenarios are in advance. Guests: Ben Branson, Founder, Seedlip and Sylva Sophie Mermin, Founder, Trotters Childrenswear Margaret Heffernan, former CEO, entrepreneur, author and professor of practice at the university of Bath school of management Production team: Presenter: Evan Davis Producer: Sally Abrahams Production co-ordinator: Katie Morrison Sound: Nathan Chamberlain and Gareth Jones Editor: Matt Willis

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