Throughline

Looksmaxxing, weight loss, and muscle building have fueled a massive craze for injectable peptides. Some natural and some synthetic. These injectables have unleashed a multi-billion-dollar gray-market industry online and a high-stakes frontier for the pharmaceutical industry. Today, we reach back to the quest to manufacture the first peptide-based medicine: Insulin.

Guests:

Alison Li, historian of science and medicine, author of J. B. Collip and the Development of Medical Research in Canada: Extracts and Enterprise

Grant Maltman, curator of Banting House National Historic Site

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From dating shows to police interrogation rooms, the polygraph test has long been marketed as a way to detect deception. But can it really? And who decided we needed a truth machine in the first place? In this episode, a Throughline listener sends us on a quest to uncover the story of the lie detector.

Guests:

Ken Alder, professor of history at Northwestern University and author of The Lie Detectors: The History of an American Obsession

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The Eighth Amendment. What is cruel and unusual punishment? Who gets to define and decide the amendment's boundaries? And how did the Constitution's authors imagine it might change? In this hour, the shifting definition of cruel and unusual punishment. 

This episode was originally published in January 2025. 

Guests:

John Bessler, law professor at the University of Baltimore School of Law, and adjunct professor at the Georgetown University Law Center. Author of The Death Penalty's Denial of Fundamental Human Rights.

Carol Steiker, law professor at Harvard Law School and author of Courting Death: the Supreme Court and Capital Punishment.

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Call it standing ovation inflation: these days, it feels like it's mandatory to stand and clap for live performances. Has our please clap era gone too far? That's what one Throughline listener wanted to know. So we traced the winding road from Shakespeare’s epilogues to Broadway divas to ridiculously long film festival ovations… and how they helped engineer the way we applaud.

Guests:

Roger Gilbert, professor in the Department of Literatures in English at Cornell

Kyle Buchanan, reporter and columnist for the New York Times

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NPR’s Anas Baba is one of the last remaining journalists in Gaza working full-time for an American news organization. A year into the ceasefire, more than 1400 people have been killed in Israeli attacks, nearly 5,000 injured. And those numbers rise nearly every day. What has the last year looked and felt like on the ground? In this episode, Baba takes us through four seasons of ceasefire—as both a resident trying to survive and a reporter trying to document reality.

Guests:

Anas Baba, NPR Gaza reporter

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