Biohacking Beauty: The Anti-Aging Skincare Podcast

Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.
In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.
The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.
If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.
What's Discussed:
(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.
(04:10) Why skin is one of the most mitochondria-dense organs in your body.
(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.
(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.
(16:30) The second half of the decline almost no skincare addresses.
(19:45) The master regulator that decides whether your cells can hire.
(24:00) The two columns of mitochondrial biology and why most brands only work in one.
(32:10) Why this is a ten-year strategy, not a two-week one.
Resources Mentioned:
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.
For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.
In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.
If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.
What's Discussed:
03:15 Why supplements are the "Wild West" of holistic health.
08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.
15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.
22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.
29:45 Why your meditation practice may be failing because of a supplement.
37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.
46:08 The future of multi-omics testing and personalized protocols.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Tyler Panzner:
Website: drtylerpanzner.com
Instagram: @drtylerpanzner
Facebook: Dr. Tyler Panzner
Linkedin: Tyler Panzner, Ph.D.
YouTube: @drtylerpanzner
FREE Guides: drtylerpanzner.com/free-guides
1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourney
Quieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page

Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.
This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?
In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering at Dave Asprey's Beyond Conference and walk you through the 3-pillar framework that replaces traditional anti-aging skincare with longevity science in mind.
Because the results you can feel today and results you can measure in ten years are not the same thing. And we think you deserve both.
Let's dive in.
What's Discussed:
(2:29) The gap no one in longevity talks about.
(3:06) Why your moisturizer is 38 years behind your supplements.
(6:21) The 12 Hallmarks of Aging, decoded.
(9:42) Pillar 1: The master pathway of skin aging.
(12:18) Why NAD in a jar doesn't work (and what does).
(14:22) The cellular housekeeping system that quietly shuts down with age.
(15:17) The peptide that affects 32% of your skin's genome.
(16:55) Pillar 2: The software updates your cells stop sending.
(20:09) The PRP lineage that changed regenerative aesthetics.
(22:54) Pillar 3: The pillar our community doesn't want to hear about.
(29:09) The protocol, tiered by where you're starting.
(37:55) How Young Goose fits into what you're already doing.
(40:32) The two tests we're building to measure skin longevity.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare
Head to younggoose.com/products/youth-body-cream for 20% off

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.
In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.
We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.
What's Discussed:
(01:06) Why skin needs autophagy more than almost any other organ
(03:07) The cells on your face that may be older than your car
(04:25) The 2013 paper that linked autophagy failure to dermatitis
(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen
(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis
(18:38) The 2019 Drexel rapamycin trial that proved this works in humans
(23:22) The 2024 spermidine study that changes how we think about autophagy
(29:51) Why your skin barrier collapses without this one molecule

Resources Mentioned:
Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/
2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/
Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.
From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.
We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.
This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.
What's Discussed:
(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out
(3:14) What autophagy actually means, and why the science world ignored it for 30 years
(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize
(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works
(10:22) Why autophagy is not destruction, and what this means for your collagen supplements
(16:44) The two master switches controlling whether your cells build or clean
(20:10) The everyday habit silencing your body's most powerful anti-aging system
(26:17) Why aging skin isn't broken, it has just never been told to clean
Resources Mentioned:
Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadi
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare