#496 Hotcakes: Cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime BP meds, Carpal Tunnel Syndrome & RA, & Finerenone for HFpEF
Join us as we review recent practice-changing articles on cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime administration of blood pressure meds, carpal tunnel syndrome & rheumatoid arthritis , & FDA approval of finerenone for HFpEF. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Rahul Ganatra (@rbganatra), Nora Taranto (@norataranto) and Matt Watto (@doctorwatto).
Claim CME for this episode at curbsiders.vcuhealth.org!
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Credits
Written and Hosted by: Rahul Ganatra MD, MPH; Nora Taranto MD, Paul Williams, MD, FACP, Matthew Watto MD, FACP
Cover Art: Rahul Ganatra MD, MPH
Reviewer: Emi Okamoto, MD
Technical Production: Pod Paste
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Show Segments
Intro, disclaimer
CBD-induced liver injury
IV Iron in HFrEF
Bedtime administration of BP medications
Carpal tunnel syndrome and RA
FDA approves Finerenone for HFpEF
Outro
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#495 Fungal Infections -Histo/Blasto/Cocci with Dr. Andrej Spec
Why we need to stop calling them “endemic” mycoses & more fungi fun!
Feeling muddled about endemic mycoses? We tackle the clinical presentation of diseases like histoplasmosis, blastomycosis, and coccidioidomycosis, the importance of testing, and how to diagnose fungal infections with our esteemed guest Dr. Andrej Spec, MD!
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Show Segments
Introduction and icebreaker, Fish Club?! 00:00
Case 1 from Kashlak 07:27
Diagnostic framework for dimorphic fungi 11:58
Imaging presentations for fungal pneumonia, diagnostic schemas 18:23
Testing options 27:48
Treatment options 35:44
Dimorphic Fungi Mnemonics 45:50
Retail testing for mold 48:47
Case 2 from Kashlak 56: 42
Takeaways and Conclusions 1:05:19
Credits
Producer, Writer, Show Notes: Beth “Garbs” Gasperlin MD
Infographic and Cover Art: Zoya Surani
Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP, Beth Gasperlin MD
Reviewer: Leah Witt Gaspard MD
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Andrej Spec MD
Disclosures
Dr. Spec reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.
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#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds
Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI).
Claim CME for this episode at curbsiders.vcuhealth.org!
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Show Segments
00:00 Intro
03:00 Guest bio and hobby
04:25 Case of Charles Fleur Fontaine
06:00 Risk factors and epidemiology
08:00 Antibiotic hierarchy of risk
10:00 Diagnosis, testing strategies
14:00 Defining severity
17:30 Treatment options
20:00 Microbiome recovery strategies
24:00 Probiotics and postbiotics
27:00 Infection control counseling
30:00 C. diff and colon cancer
32:00 Recurrent C. diff strategies
35:00 Why some FMT and bezlotoxumab were discontinued
38:00 Microbiota replacement therapies
43:00 Prophylaxis strategies
45:00 Future therapies and ongoing research
47:00 Audience Q&A
52:00 Outro
Credits
Written and Produced by: Matthew Watto, MD, FACP
Cover Art and Infographic by:
Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP
Reviewer: Sai S Achi MD,MBA,FACP
Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
Technical Production: PodPaste
Guest: Cynthia Sears MD
Disclosures
Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended.
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Bonus: Hypermobility Q&A with Bendy Bodies Dr. Linda Bluestein
In this special bonus episode, Dr. Linda Blustein (Bendy Bodies https://bit.ly/m/BendyBodies) addresses listener questions about Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders.
00:00 – Introduction
00:59 – Can PCPs diagnose hEDS without a geneticist?
03:19 – Limitations of the Beighton Score
05:40 – 2017 hEDS criteria & upcoming revisions
10:29 – How to find a knowledgeable provider
12:52 – SVT vs POTS in a patient with EDS family history
19:53 – How to ask your provider if they’re comfortable treating dysautonomia
22:17 – MTHFR variants and hEDS
29:23 – Celiac, gluten sensitivity & EDS
31:48 – Food allergy vs sensitivity testing
34:11 – Lipoedema and hypermobility
39:00 – LDN, Ketotifen, and Cromolyn
43:41 – Medication sensitivity in EDS/POTS/MCAS patients
45:47 – Wrap up and resources
FIGS
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Locumstory
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Grammarly
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REBOOT: #452 NAFLD/MASLD with Dr. Elliot Tapper
We have a classic Curbsiders episode for you. Expert guest Dr. Elliot Tapper (@ebtapper) shares his framework for approaching NAFLD/MASLD and the treatment tools he recommends including lifestyle modifications and medications.
Acerca de The Curbsiders Internal Medicine Podcast
Supercharge your learning and enhance your practice with this Internal Medicine Podcast featuring board certified Internists as they interview the experts to bring you clinical pearls, practice-changing knowledge, and bad puns. Doctors Matthew Watto, Paul Williams, and friends (a national network of students, residents, and clinician-educators) deliver a little knowledge food for your brain hole. Yummy! No boring lectures here, just high-value content and a healthy dose of humor. Fantastic for Internal Medicine, Family Medicine, Primary Care, and Hospital Medicine.