ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research

Among patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), treatment with aficamten resulted in significantly greater improvements in exercise capacity and quality of life compared with placebo over 36 weeks. The ACACIA-HCM findings offer promising news for patients and clinicians managing this challenging condition. Importantly, the trial is the first to demonstrate clinically meaningful symptomatic and functional benefits with a therapy designed to address the root cause of the disease. 

In this episode, Matthew Martinez, MD, FACC and Ahmad Masri, MD, FACC evaluate "ACACIA-HCM: Aficamten for symptomatic nonobstructive hypertrophic cardiomyopathy".

The PRESC1SE-MI trial evaluated whether an accelerated diagnostic pathway for suspected myocardial infarction could improve Emergency Department efficiency without compromising safety. Compared with standard care, the accelerated strategy demonstrated similar safety but did not reduce Emergency Department length of stay. 

In this episode, Jeroen J. Bax PhD, MD, FACC and Jasper Boeddinghaus, MD discuss "PRESC1SE-MI: Safety and efficacy of the ESC 0/1-hour Pathway".

As TAVI expands to younger and healthier patients, valve durability has become an increasingly important consideration. However, the optimal antithrombotic strategy to support long-term valve function remains unclear. This trial compared antiplatelet monotherapy with NOAC monotherapy to help address this unmet need. 

In this episode, Deepak L. Bhatt MD, MPH, MBA, FACC and Øyvind H. Lie, MD, PhD, MSc examine the results of "ACASA-TAVI: Antithrombotic therapy after TAVI".

Catheter ablation is frequently performed to improve quality of life in patients with atrial fibrillation (AF). This randomized multicenter trial compared catheter ablation with a sham procedure to assess the true effect of the intervention on AF-related quality of life. 

In this episode, Clyde W. Yancy, MD, MACC and Rolf Wachter, MD discuss the results of "PVI-SHAM-AF: Pulmonary vein isolation versus SHAM in AF".

The FUND-HF trial found that financial support provided soon after hospitalization is a practical strategy for improving medication adherence among economically vulnerable patients with heart failure and reduced ejection fraction. These results lay the groundwork for future trials designed to examine the durability of these benefits and their effects on health-related quality of life and clinical outcomes. 

In this interview, Alison L. Bailey, MD, FACC and Ambarish Pandey, MD, MS examine the effect of financial support on quality of life and medication adherence among low-income patients following hospitalization for heart failure.