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Show Me the Science with Luke O'Neill

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Show Me the Science with Luke O'Neill
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  • The Science of Cellulitis
    This week, Professor Luke O’Neill turns his microscope to a condition he knows all too well — cellulitis. It’s one of the most common bacterial infections there is, affecting about one in every 500 people each year. The skin turns red, swollen, and sore, and you might even feel flu-ish as your immune system fights back. Left untreated, it can spiral into sepsis, making early diagnosis vital. Listener Joanie suggested this week’s theme, and you can do the same by emailing Luke at [email protected]. As Luke explains, cellulitis happens when bacteria slip through tiny breaks in the skin — a scratch, a cut, even an insect bite — and start multiplying. He suspects that’s how he picked it up himself earlier this year. Rates of cellulitis are on the rise, with hospitals seeing more admissions, especially in settings where people live in close quarters: nursing homes, homeless shelters, and college dorms. Obesity and antibiotic resistance may also be fuelling the increase. Treatment is straightforward (antibiotics usually clear it up) but prevention is even better. Keeping skin clean and moisturised, and treating any breaks promptly, can stop it taking hold. And it’s not just humans. Cats, dogs and even horses can suffer from cellulitis, with vets watching closely for swelling and lameness. In fact, that old-fashioned poultice once used to “draw out” infection still has its place — at least in the stable. From microbes to moisturiser, Luke explores how our skin keeps the world out. And what happens when it can’t.
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  • The Science of Hallowe’en
    This week, Show Me The Science gets a little darker — and a little stranger. Professor Luke O’Neill dives into the science of Hallowe’en, tracing its roots back to the Celtic festival of Samhain, the ancient Irish celebration marking the start of winter — that “dead time” when the veil between worlds was said to thin. It’s not about ghosts and ghouls, Luke explains, but about remembering ancestors, lighting bonfires, and wearing masks to mark the turning of the seasons. Around those fires, people bonded, built resilience, and reaffirmed community — something modern psychology still recognises as vital in times of darkness and uncertainty. Luke explores the science of fear: how the body reacts when startled, from adrenaline spikes to endorphin release, and why a good fright, once we recover from it, can actually make us stronger. Researchers have even measured these effects in saliva! But don’t expect Luke to be queueing up for a horror marathon — he admits he doesn’t get the same thrill others do from being scared senseless. There’s also a scientific story behind our favourite monsters. The myths of vampires and werewolves, Luke reveals, may have stemmed from a rare inherited condition called porphyria, which causes sensitivity to light, red-stained teeth, and even hair growth and behavioural changes — symptoms that once seemed supernatural. And diseases like plague or tuberculosis, which sometimes left victims appearing to rise from the dead, helped fuel the legend of the undead. From Bram Stoker’s Dracula — possibly inspired by both the actor Henry Irving and the medical realities of syphilis — to the theory that “Dracula” could derive from the Irish “droch fhola,” or “bad blood,” Luke connects folklore, medicine, and etymology in classic Show Me The Science style. And there’s even a royal twist: King George III famously suffered from porphyria, and through royal intermarriage, the disease spread across Europe’s bloodlines — adding a touch of genetic truth to the vampire myth. This special Hallowe’en edition was produced in collaboration with the Music Technology course at South East Technological University. The haunting original music was composed and recorded by Billy Doran.
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  • The Science of Regulatory T Cells
    Ever wondered what keeps your immune system in check when it starts misbehaving? On this week’s podcast, Professor Luke O’Neill explains the world of regulatory T cells—the immune system’s very own “military police.” These tiny guardians stop other cells from attacking the body, helping prevent autoimmune diseases and keeping us healthy. Luke takes us through the Nobel Prize-winning discoveries of Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, who cracked the secrets of immune tolerance. Back in 1995, Sakaguchi discovered these remarkable regulatory T cells, proving that the immune system is far more sophisticated than previously thought. Brunkow and Ramsdell uncovered the critical role of the Foxp3 gene in autoimmune diseases, and Sakaguchi later linked the Foxp3 gene to the development of these life-saving cells. Luke even shares insights from a recent encounter with Sakaguchi himself! If you’ve ever been curious about how the body avoids attacking itself, or how groundbreaking immunology research leads to real-world insights, this episode is your backstage pass to the science of regulatory T cells. Got questions, ideas, or thoughts for Luke? Email him directly at [email protected]
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  • The Science of Performance Enhancing Drugs
    An Irish Olympian has decided to take a bold and controversial leap. Swimmer Shane Ryan has retired from conventional competition to join the Enhanced Games, a new event where athletes will be allowed to use performance-enhancing drugs. In this week’s podcast, Professor Luke O’Neill looks at the science and the ethics behind this radical sporting experiment. The Games’ creator, Aron d’Souza, says he wants to celebrate human potential without the limits imposed by anti-doping rules. Backed by investors such as Peter Thiel and Donald Trump Jr, the Enhanced Games are due to take place in Las Vegas in May 2026, offering up to a million dollars for breaking a world record. Luke dives into the biology behind enhancement. He explains how testosterone builds muscle mass, how growth hormone boosts recovery, and how EPO (erythropoietin) increases red-blood-cell production and endurance. These substances can deliver extraordinary results, but they also carry dangerous side effects: heart damage, infertility, high blood pressure, diabetes, kidney failure, and even seizures. Beyond drugs, the Games will also allow prosthetic limbs and high-tech running shoes, pushing the boundary between sport and science fiction. Critics, including the IOC and US Anti-Doping Agency, say it will destroy fair play. D’Souza insists athletes will be medically supervised and screened for safety. Luke asks what this says about the times we live in — an “age of enhancement” where medicine, tech and ambition blur together. From longevity clinics to performance labs, we’re already chasing upgrades to our own biology. It might sound like The Hunger Games, but it’s very real — and it’s coming soon.
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  • The Science of Accents
    Taylor Swift has changed her accent over the years – and science can prove it. A quirky new study from the University of Minnesota analysed hours of Swift interviews to show how her voice shifted depending on what era she was in. For Professor Luke O’Neill, it’s the perfect excuse to dive into one of his favourite subjects: accents and dialects. From the five distinct dialects of Ireland to the 30-plus versions of English spoken worldwide, this week’s podcast looks at why we sound the way we do – and why accents change over time. He explains how Elizabethan English is still alive in pockets of North America, why Irish “borrow words” like galore, slew, baloney and hooligan have shaped English, and how the Beatles made regional accents cool in the 1960s. There’s science, history, and plenty of fun in this trip through the way we speak – with Luke revealing his two favourite English accents (spoiler: think West Country warmth and Southern US drawl). And yes, he’s very happy that the Irish accent now ranks among the coolest in the world. Got an accent story of your own, or an idea for a future episode? Drop Luke an email at [email protected].
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Acerca de Show Me the Science with Luke O'Neill

Have you ever wondered why we laugh or if you can really die of a broken heart? Join Professor Luke O'Neill on ‘Show Me the Science’ as he tackles a different issue each week; from the serious to the silly, all explained through science. This Newstalk production will open the world of science to people of all ages. New episodes every Thursday. Show me the Science is with thanks to B Braun. Listen and subscribe to Show Me the Science with Luke O'Neill on Apple Podcasts and Spotify. Download, listen and subscribe on the Newstalk App.   You can also listen to Newstalk live on newstalk.com or on Alexa, by and asking: 'Alexa, play Newstalk'
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