Security You Should Know

In this episode, Joshua Knox, Principal Cybersecurity Strategist and AI Lab Tech Lead at Horizon3, explains how the company's NodeZero platform runs continuous, autonomous offensive assessments that surface exploitable attack chains and dangerous misconfigurations, not just vulnerabilities, so teams can prioritize and validate fixes on a repeatable basis. Joining him are Jesse Webb, CISO and SVP of Information Systems at Avalon Healthcare Solutions, and Ryan Brown, Director and Head of Cybersecurity Operations at Children's National Hospital.

Want to know:

Why are vulnerability scanners disrupting security programs, and is it really disruption or a prioritization problem?
How does NodeZero scope an assessment so it doesn't put patient-connected medical devices at risk?
Can NodeZero identify the criticality of a specific device, like a PACS machine, once it's discovered on the network?
How does Horizon3 keep HIPAA data "production safe" when NodeZero is actively assessing a healthcare network?
Why does running attacks through code-bound modules, rather than a freeform agent, make autonomous pentesting more reliable?
How do autonomous pentest reports hold up as an audit artifact next to a traditional, human-led penetration test?
What happens when a legacy contract requires a human-proctored external pentest?
How does Horizon3 train its models without using data from customer environments?
What's the one thing about NodeZero that surprises CISOs most once they start using it?

Huge thanks to our sponsor, Horizon3
Horizon3 is the AI-native proactive security company behind NodeZero®, an autonomous pentesting platform that helps organizations prove their defenses work. NodeZero safely identifies exploitable attack paths, verifies fixes, and enables continuous security validation at machine speed so teams can stay ahead of AI-powered threats.

In this episode, Ashu Savani, co-founder of TryHackMe, explains how the company's Live Breach product puts teams inside fully-executed, realistic breach simulations built around the threat actors and tech stacks they face, building the reflexes and reporting security leaders need before a real incident hits. Joining him are Roland Toussaint, Senior Director of Incident Response and Security Engineering at ChenMed, and Heather Hinton, CISO at Sitecore.

Want to know:

How can a simulated environment realistically reflect a security team's actual tech stack and the threat actors they care about?
Can TryHackMe's reporting help security leaders prove upskilling progress to auditors and cyber insurance carriers?
How does TryHackMe help teams train for incidents caused by their own people, not just outside attackers?
How granular can training get: can a team run a meaningful exercise in just 15 to 20 minutes?
How are TryHackMe's custom exercises tiered and packaged across its plans?
What's TryHackMe's track record getting cyber insurance carriers to accept its exercises as sufficient proof of readiness?
Does TryHackMe offer anything built specifically around HIPAA for healthcare organizations?
Why is crisis communication often more under-rehearsed than technical response, and how does TryHackMe help teams practice it?

Check out the episode for the answers you need.

Huge thanks to our sponsor, TryHackMe

Live Breach challenges security teams to test their incident response against a rogue AI agent in a realistic, three-hour exercise. The campaign uses a compelling AI-driven attack scenario to create urgency, while highlighting the low-risk setup, actionable readiness insights and practical value of testing teams before a real incident occurs.
Business applicants only, 18+. Applications open 7 October 2026 and close 18 October 2026 at 23:59 EST time. Six companies are selected by a TryHackMe panel from eligible applications, against published criteria; each receives one complimentary simulated Live Breach exercise. No purchase necessary. Full terms: http://tryhackme.com/legal/live-breach-giveaway-terms

In this episode, Joseph Perla, founder and CEO at TrustedRouter, explains how his company's confidential-computing-based LLM router lets teams send prompts to hundreds of AI models while cryptographically verifying, rather than simply trusting, that no one, including TrustedRouter itself, can see the data passing through. Joining him are TC Niedzialkowski, former head of IT & security at Opendoor, and Keith McCartney, svp of security and IT at DNAnexus.

Want to know:

Why hasn't the AI privacy problem already been solved, given how many tools and architectures already exist?
What's wrong with the "zero data retention" promises most AI providers offer today?
How does a confidential virtual machine let a company verify, instead of just trust, that its own router isn't looking at its prompts?
For a use case like HIPAA-covered medical data, does TrustedRouter provide one complete, auditable path from a user's machine to the model and back?
How does remote attestation confirm end-to-end encryption down to the chip level?
Does TrustedRouter's SOC 2 Type 2 attestation cover the AI workload itself, or just its own SaaS interface?
Can customers restrict which data centers or jurisdictions their AI workloads run in?
What happens to a company's existing AI usage monitoring once it starts routing through TrustedRouter?

Check out the episode for the answers you need.

Huge thanks to our sponsor, TrustedRouter
TrustedRouter is the open-source AI gateway for teams that need privacy with proof. It routes hundreds of models through attested confidential compute, keeps prompts and outputs out of logs, verifies the code handling each request, and adds provider failover, spend controls, and OpenAI-compatible APIs for production AI systems.

In this episode, Dean Shroll, senior director of sales engineering at ThreatDown, explains how the company's Nebula and OneView consoles simplify protection across Mac, Linux, and Windows endpoints while its managed detection and response team absorbs the 24/7 monitoring that resource-constrained teams can't staff on their own. Joining him are Jonathan Waldrop, CISO at Acoustic, and Arif Hameed, CISO at C&R Software.

Want to know:

Why is managing security for resource-constrained organizations suddenly getting more attention?
How does ThreatDown keep its console simple without sacrificing depth across Windows, Mac, Linux, and cloud environments?
Where does ThreatDown draw the line between what it automates and what still needs a human analyst?
How does the platform distinguish suspicious behavior from normal DevOps activity without drowning teams in false positives?
What guardrails exist to stop overly broad exclusions from opening up a device?
Who owns what when an MDR provider is involved, and where does that responsibility actually end?
How should a CISO justify an MDR investment to the board when nothing bad happens?

Check out the episode for the answers you need.
Huge thanks to our sponsor, ThreatDown
ThreatDown delivers elite Managed Detection and Response purpose-built for resource-constrained teams with high-efficacy protection without complexity. Combining artificial intelligence and expert analyst judgment, ThreatDown intercepts sophisticated attacks with speed and accuracy, scaling security effortlessly. Recognized by MRG Effitas, AVLab, and G2, ditch fragmented tools for fast, 24/7 protection without overhead.

In this episode, Leo Taddeo, CEO and President at AppGate, explains how the company's zero trust network access platform cloaks internet-facing infrastructure from discovery, uses direct-routed architecture instead of cloud-routed hairpinning to avoid the latency tax, and layers in continuous, context-aware policy checks that go beyond device posture and MFA. Joining him are Ross Young, co-host of CISO Tradecraft, and Derek Fisher, Director of the Cyber Defense and Information Assurance Program at Temple University.

Want to know:

Why does securing remote access remain one of the top attack vectors year after year?
How does AppGate's direct-routed architecture avoid the latency and throughput limits of cloud-routed competitors?
What happens to a user's access when the circumstances that justified it change, like a closed service ticket?
How does cloaking network infrastructure stop an adversary's reconnaissance before it starts?
What's the fallback when a controller hosted in a customer's own data center goes down?
How does AppGate defend against credential replay and man-in-the-middle attacks that bypass MFA entirely?
What does AppGate's per-user licensing model mean for organizations managing multiple devices and enclaves?

Check out the episode for the answers you need.

Huge thanks to our sponsor, AppGate

AppGate secures and protects an organization's most valuable assets with its high performance Zero Trust Network Access (ZTNA) solution. AppGate ZTNA is the only direct-routed Zero Trust solution built for peak performance, superior protection and seamless interoperability. AppGate safeguards enterprises and government agencies worldwide. Learn more at appgate.com.