What if mental health care worked more like cancer treatment—tailored to the individual, informed by biology, and driven by data? Charles Marmar, MD, Chair of Psychiatry at NYU Grossman School of Medicine, takes us through the latest advances in precision psychiatry. From brain imaging to digital phenotyping, Dr. Marmar outlines the tools shaping a future where treatment is fully customized. He also shares stories from the front lines: a patient whose depression was treated with the help of a brain biopsy, why PTSD and depression aren’t one-size-fits-all, and how quantum computing could radically accelerate psychiatric research.🔍 Topics Covered00:00 Introduction02:24 Personalized Treatment Approaches05:13 Challenges in Precision Psychiatry11:12 The Role of Genomics and Brain Imaging23:35 Digital Psychiatry and AI25:57 Quantum Computing in Psychiatry33:04 Future of Precision Psychiatry37:22 Conclusion📚 Related ResourcesCharles Marmar, MD – NYU Faculty ProfileNYU Langone Psychiatry Adriana Heguy, PhD – NYU Faculty Profile Javad Shabani, PhD – NYU Faculty Profile🙌 Support & SubscribeIf this episode challenged your thinking, like, share, and subscribe to help bring smart, science-forward conversations to a wider audience.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle
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43:30
The Schizophrenia Puzzle is Solvable
There’s a care model for schizophrenia that actually works—why isn’t it everywhere? On this episode, W. Gordon Frankle, MD, MBA, Vice Chair of Psychiatry at NYU Langone Health, shares how his team in Brooklyn is building a new model for treating serious mental illness—one rooted in long-term, relationship-driven, team-based care. From wraparound services to precision psychiatry, this conversation explores what happens when you bring humanity, structure, and innovation to a population too often left behind.Also discussed:The first novel schizophrenia drug in over 50 years (Cobenfy)Why clozapine is underused—and how that may finally changeThe potential of brain imaging and biomarkers in psychiatric treatmentWhat a real community mental health system looks likeWhy trust, not just treatment, is essential for recovery🔍 Topics Covered00:00 Introduction00:30 Dr. Frankle's Current Work01:08 Advancements in Schizophrenia Research02:29 Challenges and New Treatments in Schizophrenia05:02 Precision Medicine in Psychiatry05:59 PET Scans and Brain Energetics09:46 Barriers to Effective Treatment11:51 Clozapine and Treatment Access13:38 Wraparound Services and Community Care14:46 Early Screening and Public Health Interventions18:32 Mandated Treatment and Patient Engagement30:08 Homelessness and Mental Health34:54 Future Directions in Schizophrenia Treatment38:09 Conclusion📚 Related ResourcesW. Gordon Frankle, MD, MBA Schizophrenia care at NYU Langone NYU Langone Hospital—Brooklyn 3 Things to Know About Cobenfy (Yale Medicine) 🙌 Support & EngageIf you enjoyed this episode, please like, share, and subscribe to support real conversations about transforming mental health care.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle
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38:51
How Psychedelics Rewire the Brain
How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone’s Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.🔍 Topics Covered:00:00 Introduction00:15 Dr. Siegel's Current Work01:01 Past Research and Human Psilocybin Imaging Study02:39 Understanding Brain Changes and Biomarkers06:13 Mechanisms of Action and Plasticity12:51 Surprising Findings and Context Dependence16:34 Challenges and Future Directions in Psychedelic Research20:46 Advanced Imaging and Personalized Treatment Plans24:15 Setbacks and Lessons in Psychedelic Medicine28:40 Emerging Areas in Neuropsychopharmacology31:46 Conclusion📚 Related Resources:Joshua Siegel, MD, PhD NYU Langone Health’s Center for Psychedelic MedicineThe Multidisciplinary Association for Psychedelic Studies (MAPS)“Psychedelic and Dissociative Drugs as Medicines” (NIH) 🙌 Support & Engage: Enjoyed this episode? Like, comment, and share to support science-based conversations about mental health.🔔 Don’t forget to subscribe for more interviews with top psychiatric researchers.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle
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32:11
Can AI Help Prevent PTSD?
What if a simple conversation in the emergency room could reveal who’s most at risk for PTSD before symptoms even begin? Katharina Schultebraucks, PhD, shares her innovative work on using machine learning to forecast mental health outcomes and explains how AI could revolutionize how we detect, prevent, and treat psychiatric disorders. Dr. Schultebraucks is Co-Director of the Computational Psychiatry Program and Associate Professor in the Department of Psychiatry and Population Health at NYU Grossman School of Medicine.🔍 Topics Covered00:00 Introduction00:23 Current Work and Research Focus01:29 Objective Measures in Psychiatry02:50 Predicting PTSD Risk04:28 Early Preventive Interventions05:47 Machine Learning in Mental Health09:49 Challenges and Surprises in Research22:46 Burnout in Emergency Department Providers27:17 Precision Psychiatry and Future Directions29:35 Conclusion📚 Related Resources-Katharina Schultebraucks, PhD -Computational Psychiatry Program in NYU Langone’s Department of Psychiatry -“Dissecting racial bias in an algorithm used to manage the health of populations” by Ziad Obermeyer, et al -PTSD Treatment at NYU Langone Health 🔔 Subscribe for more conversations at the intersection of mental health and innovation.📢 Like, comment, and share if this episode sparked your thinking.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle
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30:06
ADHD at School: What Actually Helps
How do you help a child with ADHD stay organized, on task, and confident in school? Richard Gallagher, PhD, a child and adolescent psychologist at NYU Langone Health, shares groundbreaking research on organizational skills training for children with ADHD—a behavioral treatment that’s changing lives and improving classroom performance. This episode dives into how executive functioning challenges manifest in real life, the strengths (and limits) of technology, and the power of parent training and therapeutic coaching to help children thrive.Dr. Richard Gallagher is Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine, and Director of the Organization Skills Program.🔍 Topics Covered00:00 Introduction00:19 Current Research on Organizational Skills01:06 Executive Functioning and Practical Interventions02:37 Impact of Interventions on ADHD04:41 Expanding Research and Brain Connectivity05:08 Medication and Organizational Skills08:11 Technology in ADHD Assessment15:39 Effective Parenting Styles for ADHD23:10 Non-Pharmacological Treatments and Future Research25:58 Conclusion and Final Thoughts📚 Related Resources👨⚕️More about Dr. Richard Gallagher 🔬 NYU Child Study Center 📘 “Organizational Skills Training for Children with ADHD” by Richard Gallagher, Howard B. Abikoff, and Elana G. Spira 📝 CHADD Parent Training Resources📈 CDC ADHD Parent Guide🙌 Support & EngageIf this episode was helpful, please like, share, and subscribe to support the series and spread awareness about evidence-based ADHD care.Visit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle
A podcast for clinicians about the latest psychiatric research. Host Thea Gallagher, PsyD, of NYU Langone Health interviews world-leading researchers about advances in their respective fields, gaining insights that clinicians can apply today.
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