The TWIML AI Podcast (formerly This Week in Machine Learning & Artificial Intelligence)

• π0: A Foundation Model for Robotics with Sergey Levine - #719

  Today, we're joined by Sergey Levine, associate professor at UC Berkeley and co-founder of Physical Intelligence, to discuss π0 (pi-zero), a general-purpose robotic foundation model. We dig into the model architecture, which pairs a vision language model (VLM) with a diffusion-based action expert, and the model training "recipe," emphasizing the roles of pre-training and post-training with a diverse mixture of real-world data to ensure robust and intelligent robot learning. We review the data collection approach, which uses human operators and teleoperation rigs, the potential of synthetic data and reinforcement learning in enhancing robotic capabilities, and much more. We also introduce the team’s new FAST tokenizer, which opens the door to a fully Transformer-based model and significant improvements in learning and generalization. Finally, we cover the open-sourcing of π0 and future directions for their research. The complete show notes for this episode can be found at https://twimlai.com/go/719.

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• AI Trends 2025: AI Agents and Multi-Agent Systems with Victor Dibia - #718

  Today we’re joined by Victor Dibia, principal research software engineer at Microsoft Research, to explore the key trends and advancements in AI agents and multi-agent systems shaping 2025 and beyond. In this episode, we discuss the unique abilities that set AI agents apart from traditional software systems–reasoning, acting, communicating, and adapting. We also examine the rise of agentic foundation models, the emergence of interface agents like Claude with Computer Use and OpenAI Operator, the shift from simple task chains to complex workflows, and the growing range of enterprise use cases. Victor shares insights into emerging design patterns for autonomous multi-agent systems, including graph and message-driven architectures, the advantages of the “actor model” pattern as implemented in Microsoft’s AutoGen, and guidance on how users should approach the ”build vs. buy” decision when working with AI agent frameworks. We also address the challenges of evaluating end-to-end agent performance, the complexities of benchmarking agentic systems, and the implications of our reliance on LLMs as judges. Finally, we look ahead to the future of AI agents in 2025 and beyond, discuss emerging HCI challenges, their potential for impact on the workforce, and how they are poised to reshape fields like software engineering. The complete show notes for this episode can be found at https://twimlai.com/go/718.

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• Speculative Decoding and Efficient LLM Inference with Chris Lott - #717

  Today, we're joined by Chris Lott, senior director of engineering at Qualcomm AI Research to discuss accelerating large language model inference. We explore the challenges presented by the LLM encoding and decoding (aka generation) and how these interact with various hardware constraints such as FLOPS, memory footprint and memory bandwidth to limit key inference metrics such as time-to-first-token, tokens per second, and tokens per joule. We then dig into a variety of techniques that can be used to accelerate inference such as KV compression, quantization, pruning, speculative decoding, and leveraging small language models (SLMs). We also discuss future directions for enabling on-device agentic experiences such as parallel generation and software tools like Qualcomm AI Orchestrator. The complete show notes for this episode can be found at https://twimlai.com/go/717.

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• Ensuring Privacy for Any LLM with Patricia Thaine - #716

  Today, we're joined by Patricia Thaine, co-founder and CEO of Private AI to discuss techniques for ensuring privacy, data minimization, and compliance when using 3rd-party large language models (LLMs) and other AI services. We explore the risks of data leakage from LLMs and embeddings, the complexities of identifying and redacting personal information across various data flows, and the approach Private AI has taken to mitigate these risks. We also dig into the challenges of entity recognition in multimodal systems including OCR files, documents, images, and audio, and the importance of data quality and model accuracy. Additionally, Patricia shares insights on the limitations of data anonymization, the benefits of balancing real-world and synthetic data in model training and development, and the relationship between privacy and bias in AI. Finally, we touch on the evolving landscape of AI regulations like GDPR, CPRA, and the EU AI Act, and the future of privacy in artificial intelligence. The complete show notes for this episode can be found at https://twimlai.com/go/716.

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• AI Engineering Pitfalls with Chip Huyen - #715

  Today, we're joined by Chip Huyen, independent researcher and writer to discuss her new book, “AI Engineering.” We dig into the definition of AI engineering, its key differences from traditional machine learning engineering, the common pitfalls encountered in engineering AI systems, and strategies to overcome them. We also explore how Chip defines AI agents, their current limitations and capabilities, and the critical role of effective planning and tool utilization in these systems. Additionally, Chip shares insights on the importance of evaluation in AI systems, highlighting the need for systematic processes, human oversight, and rigorous metrics and benchmarks. Finally, we touch on the impact of open-source models, the potential of synthetic data, and Chip’s predictions for the year ahead. The complete show notes for this episode can be found at https://twimlai.com/go/715.

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