On balanced neural networks - with Nicolas Brunel - #34
An important discovery that has come out of computational neuroscience, is that cortical neurons in vivo appear to receive so-called balanced inputs. In the balanced state the excitatory and inhibitory synaptic inputs to a neuron are about equal, and action potentials occur when a fluctuation temporarily makes the excitation dominate. The theory, for example, explains the observed irregular firing of cortical neurons in the background state. Today's guest was one of the key developers of the theory in the late 1990s.
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1:38:59
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1:38:59
On computational neurotechnology for the clinic - with Anthony Burkitt, Nada Yousif & Esra Neufeld - #33
How can computational neuroscience contribute to developing neurotechnology to help people with brain disorders and disabilities? This was the topic of a panel debate I hosted at the 34th Annual Computational Neuroscience Meeting in Florence in July this year. Electric or magnetic recording and/or stimulation are key clinical tools for helping patients, and the three panelists have all used computational methods to aid this endeavor.
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1:00:36
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1:00:36
On IIT and adversarial testing of consciousness theories - with Christof Koch - #32
In an adversarial collaboration researchers with opposing theories jointly investigate a disputed topic by designing and implementing a study in a mutually agreed unbiased way. Results from adversarial testing of two well-known theories for consciousness, Global Neuronal Workspace Theory (GNWT) and Integrated Information Theory (IIT), were presented earlier this year. In this podcast one of the proponents and developers of IIT describes this candidate theory, and also the design of, and results from, the adversarial study.
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2:17:36
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2:17:36
On how to cure brain diseases - with Nicole Rust - #31
A promise of basic neuroscience research is that the new insights will lead to new cures for brain diseases. But has that happened so far? Today's guest, an accomplished professor of neuroscience, decided to investigate. Her book "Elusive cures: why neuroscience hasn't solved brain disorders - and how we can change that" came out this summer. Here she argues that we need to consider the brain as a complex adaptive system, not as a chain of dominos as in the typical linear thinking.
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2:13:18
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2:13:18
On co-dependent excitatory and inhibitory plasticity - with Tim Vogels - #30
Synaptic plasticity underlies several key brain functions including learning, information filtering and homeostatic regulation of overall neural activity. While several mathematical rules have been developed for plasticity both at excitatory and inhibitory synapses, it has been difficult to make such rules co-exist in network models. Recently the group of the guest has explored how co-dependent plasticity rules can remedy the situation and, for example, assure that long-term memories can be stored in excitatory synapses while inhibitory synapses assure long-term stability.
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