In this episode Andrea Samadi welcomes back Dr. David Stephens to explore his new book, The Glucose Protocol, and the science showing how targeted glucose can restore brain function, improve mental clarity, and reduce symptoms linked to diabetes, autoimmune disorders, and chronic stress.
They break down the difference between glucose and other sweeteners, explain why the brain prioritizes survival over higher-order thinking during stress, and share practical strategies—like on-the-spot glucose dosing—to regain focus and cognitive performance.
Dr. Stephens also discusses biomarkers, clinical observations, and upcoming practical products to make brain refueling easy, offering hopeful, science-based approaches to restore long-term brain health.
Watch interview on YouTube here https://youtu.be/zv70S5fZh2I
Today's EP 388 we’re welcoming Dr. Stephens back to the podcast to explore:
The difference between glucose and other sugars
Why blood sugar and brain glucose matter for cognitive performance
What his newest research is revealing about brain restoration
And how we can think more clearly about nutrition and brain health moving forward.
Welcome back to Season 15 of the Neuroscience Meets Social and Emotional Learning Podcast.
I’m Andrea Samadi, and here we bridge the science behind social and emotional learning, emotional intelligence, and practical neuroscience—so we can create measurable improvements in well-being, achievement, productivity, and results.
When we launched this podcast seven years ago, it was driven by a question I had never been taught to ask—
not in school,
not in business,
and not in life:
If results matter—and they matter now more than ever—how exactly are we using our brain to make these results happen?
Most of us were taught what to do.
Very few of us were taught how to think under pressure,
how to regulate emotion,
how to sustain motivation,
or even how to produce consistent results without burning out.
That question led me into a deep exploration of the mind–brain–results connection—and how neuroscience applies to everyday decisions, conversations, and performance.
That’s why this podcast exists.
Each week, we bring you leading experts to break down complex science and translate it into practical strategies that we can all apply immediately.
When the brain, body, and emotions are aligned, performance stops feeling forced—and starts to feel sustainable.
Season 14 showed us what alignment looks like in real life. We looked at goals and mental direction, rewiring the brain, future-ready learning and leadership, self-leadership, which ALL led us to inner alignment.
And now, Season 15 is about understanding how that alignment is built—so we can build it ourselves, using predictable, science-backed principles.
Because alignment doesn’t happen all at once.
It happens by using a sequence.
And when we understand the order of that sequence —
we can replicate it.
By repeating this sequence over and over again, until magically (or predictably) we notice our results have changed.
Season 15 we’ve organized as a review roadmap, where each episode explores one foundational brain system—and each phase builds on the one before it.
Rather than focusing on outcomes, hacks, or motivation alone, we examine the core brain systems that must be stable before learning, performance, and leadership can emerge.
Episodes are organized around a simple but powerful progression:
Phase 1: Regulation & Safety — the nervous system foundation for learning
Phase 2: Neurochemistry and Motivation—dopamine balance + Emotional regulation
Phase 3: Cognition & Learning — attention, memory, and executive function
Phase 4: Perception & Social Intelligence — how we read ourselves and others
Phase 5: Integration & Meaning — how experience becomes insight and growth
Each system builds upon the one beneath it, reminding us that when foundations are ignored, progress is temporary. When they are strengthened, performance becomes sustainable.
Season 15 is not a review of past episodes—we are connecting neuroscience, emotional regulation, and learning into a clear framework for improved human potential.
Because performance is not built from the top down.
It emerges from the foundations up.
PHASE 1: REGULATION & SAFETY
Staples: Sleep + Stress Regulation
Core Question: Is the nervous system safe enough to learn?
Anchor Episodes
Episode 384[i] — Baland Jalal
How learning begins: curiosity, sleep, imagination, creativity
Episode 385[ii] — Bruce Perry
“What happened to you?” — trauma, rhythm, relational safety
Episode 386 –Thoryn Stephens Turning biometrics (HRV, sleep data, metabolic markers) into actionable protocols.
Episode 387 Dr. Sui Wong[iii]
Autonomic balance, lifestyle medicine, brain resilience
Episode 388 Rohan Dixit
HRV, real-time self-regulation, nervous system literacy
For today's EP 388, we welcome back Dr. David Stephens, a clinical psychologist and neuropsychologist renowned for his expertise in brain function and mental health. Discover groundbreaking insights into how glucose can be a game-changer in restoring brain function, mental health, and overall productivity.
Dr. Stephens shared his compelling journey with us that led to the revelation of glucose as a crucial element in brain restoration. From understanding the perceptible differences between glucose and sugar to unraveling common myths about brain health, this conversation is packed with scientific insights that challenge traditional paradigms that explored how restoring glucose levels could revolutionize our mental, emotional, and spiritual well-being.
I believe in Dr. Stephens’ mission mostly because I’ve experienced life-changing results when I started to read labels, and cut out sugar after a podiatrist told me this would improve my health back in 2005. The results I’ve noticed are significant. But now, I understand sugar and glucose at a different level. I have lots of follow up questions for Dr. Stephens, and am excited to learn more about what he has discovered since we last spoke.
Episode Introduction
This week on The Neuroscience Meets Social and Emotional Learning Podcast, we are revisiting a past guest who joined us in December 2024 on Episode 350[iv].
Dr. David Stephens is a clinical psychologist and neuropsychologist known for his research on brain function, mental health, and the role of glucose in cognitive performance and recovery.
In our previous conversation, Dr. Stephens introduced a fascinating concept: that glucose may play a far more important role in brain restoration and mental health than many of us realize.
Since that interview, Dr. Stephens has continued his research and recently released new insights in his book Restored Hope, exploring how glucose regulation may influence cognitive performance, emotional stability, and overall brain health.
This topic is especially meaningful to me personally. Back in 2005, a podiatrist suggested I eliminate sugar from my diet to improve my health. After making that change and becoming more mindful of reading nutrition labels, I noticed significant improvements in how I felt physically and mentally.
But what I’ve learned since speaking with Dr. Stephens is that understanding sugar and understanding glucose are not the same thing—and that difference may change how we think about nutrition and brain health.
Dr. Stephens, welcome back to the podcast. How have you been since we last spoke?
Q1: Dr. Stephens, thank you for reaching back to me about your new book, and research. I’m sure you could tell that this topic is important to me. We’ve covered a few podcast episodes on “The Damaging Effects of Sugar on the Brain and Body” with research that came from my foot doctor, who had me change my diet in 2005, and my health turned around for the better. Can we review what should we understand about glucose, vs sucralose that is connected to weight gain and type 2 diabetes?
Q2: What’s important about understanding our blood sugar vs glucose levels in the brain?
Q3: I’ve also posted a comment from our last interview that gave an overview of the definition of sucrose vs sucralose. Then I wondered, is sucralose bad for our brain? Sometimes I make sugar free hot chocolate, and I know that I once looked this up. I’m sure Dr. Daniel Amen recommends Stevia as a brain-healthy sweetener, but I’m sure I once forgot, and bought Splenda by mistake. Can you explain the difference and do you agree with Dr. Amen that we should choose Stevia over Splenda?
Q4: Can you share what you have uncovered since we last spoke in December 2024? I did read what you had sent me, but I will need it translated into English. • Fructose-controlled design (with biomarker panels HRV, FDG-PET, inflammatory markers, RBANS domains). • AI assisted hypothesize generation for theory building • This book ranks
Q5: I followed some of the questions that came through on the YouTube Comments since our last episode. Many were positive, and support your research but every once in a while, someone will comment something negative about this topic. I find it interesting, because the podiatrist who told me to stop eating sugar years ago said the exact same thing. He found it difficult to fight against the criticism. What have you noticed and how do you handle people who don’t understand what you have uncovered?
Q6: What else is important for us to understand?
Q7: Some people have asked for updated information on where they can find you. Can you share the best way for people to reach you?
Dr. Stephens, I believe in your mission, and look forward to reading your new book. Thank you for sharing your research with us, and look forward to hearing what from you as you write more books on this topic, to help us to take our brain health seriously.
Key Takeaways from This Episode
1. The Brain Runs on Glucose
Glucose is the brain’s primary fuel source. When glucose regulation is disrupted, it can affect cognition, focus, emotional regulation, and mental health.
2. Not All “Sugar” Is the Same
Many people use the words sugar and glucose interchangeably, but they are chemically different and can affect the body in different ways.
Understanding these differences can help people make more informed nutrition decisions.
3. Artificial Sweeteners Raise Important Questions
Sweeteners like sucralose (Splenda) may not behave the same way as natural glucose or other sugars in the brain and body.
This is an area of ongoing research and debate, and understanding the metabolic impact of these substitutes is important.
4. Brain Health Is Deeply Connected to Metabolism
Dr. Stephens’ research suggests that metabolic processes, inflammation, and brain energy systems may play a much larger role in mental health and cognitive performance than we previously understood.
5. Science Evolves Through Debate
Innovative research often meets skepticism. Scientific progress depends on healthy debate, continued research, and open dialogue.
Listener Action Steps
1. Become Aware of Your Nutrition Labels
Start reading labels and becoming more aware of added sugars, sweeteners, and ingredients in your daily diet.
Small changes can have meaningful long-term effects.
2. Pay Attention to Your Brain Energy
Notice how your focus, mood, and energy levels respond to different foods.
Your brain’s fuel matters for performance, learning, and emotional regulation.
3. Stay Curious About New Research
Topics like nutrition, metabolism, and brain health are constantly evolving. Stay open to learning and questioning new findings. Just like we mention in this interview, there was a day that Andrea would not eat butter. Understanding glucose is another paradigm shift.
4. Prioritize Brain Health Holistically
Nutrition is only one piece of the puzzle. Brain health is also supported by:
sleep
stress regulation
exercise
recovery
social connection
Closing Summary
As we continue exploring the neuroscience behind health, performance, and learning, conversations like this remind us that our brain is deeply connected to the systems that fuel it.
Understanding how the brain uses energy—through glucose, metabolism, and nutrition—opens new doors for improving mental clarity, emotional well-being, and long-term brain health.
Dr. Stephens, thank you for returning to the podcast and for continuing to explore this important topic.
For those who want to dive deeper, we’ll link to Dr. Stephens’ latest book that you can pre-order now, and our original conversation from Episode 350 in the show notes. Feel free to reach out directly to Dr. Stephens through his contact information below.
RESOURCES:
Watch our original interview here EP 350 https://youtu.be/T0R3uvBbHPE
MORE ABOUT DR. STEPHENS
Dr. David Stephens is a seasoned clinician and leader in issues related to mental health, who has focused his efforts over the last 15 years on neuroscience. As a former supervising psychologist at the Colorado State mental hospital and a director in correctional mental health, he brings a unique perspective to the challenges faced by individuals with mental health and substance use disorders. He is a sought-after expert in the fields of brain function, mental, and correctional mental health. His work has been instrumental in shaping policies related to mental health care within correctional settings.
Dr. Stephens has spent the majority of his career training statewide directors of mental health within the correctional system on brain function as well as geriatric issues facing the nation's prisons. He served as the academic Dean of professional psychology, including both Master's and Doctoral programs. He has been interviewed several times to discuss topics related to mental health, correctional mental health, brain function, addiction, and marriage. Dr. Stephens has dedicated his life to helping educate everyone he encounters on the importance of knowing and understanding these topics.
CONNECT with DR. DAVID STEPHENS
Phone: 573 590-4638
Email:
[email protected]Website: https://www.glucoseprotocol.com/
PRE-ORDER The Glucose Protocol: A Practical and Scientific Guide to Brain Restoration of Health.
https://www.amazon.com/dp/B0GQQYNX4Z#:~:text=The%20Glucose%20Protocol,Read%20more
REFERENCES:
[i] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 384 “How Learning Begins in the Brain: Sleep, Safety and Curiosity (Revisiting Dr. Baland Jalal) https://andreasamadi.podbean.com/e/hypnagogic-genius-capture-your-best-ideas-at-the-edge-of-sleep/
[ii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 385 “Safety First: Why a Regulated Brain is the Key to Learning” (Revisiting Dr. Bruce Perry) https://andreasamadi.podbean.com/e/safety-first-why-a-regulated-brain-is-the-key-to-learning/
[iii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 387 with Dr. Sui Wong “Your Eyes: The Brain’s Early Warning System” https://andreasamadi.podbean.com/e/your-eyes-the-brain-s-early-warning-system/
[iv] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 350 “Unlocking Brain Health with Dr. David Stephens” https://andreasamadi.podbean.com/e/unlocking-brain-health-with-dr-david-stevens/