Investment Climate Podcast

Episode 115: BEAM Circular Accelerator (Powered by gener8tor): Darko Mandich on Crossing to the Other Side of the Table, Off-Take Agreements Over LOIs, and Turning Almond Waste into a Bioeconomy
In this episode, I catch up with my friend Darko Mandich — Managing Director of the BEAM Circular Accelerator (Powered by gener8tor) and Ag Practice Chair at gener8tor — for a rare look at fundraising from the investor's seat. Darko knows both sides intimately: he built and exited MeliBio, the bee-free honey pioneer (acquired by Switzerland's FoodYoung Labs), and has now crossed the table to back early-stage founders turning agricultural waste into value. He shares what genuinely surprised him about the investor side — how many internal "yeses" it takes to cut a single check, and why founder patience is so misunderstood — and makes a passionate case that the founders winning in 2026 are commercially driven, not science driven, doing far more with far less. We dig into why LOIs no longer cut it (investors now want signed off-take agreements), how gener8tor and BEAM Circular are attacking the CapEx barrier head-on by building a shared California Bioeconomy Innovation Campus in Modesto, and why California's Central Valley — with 80% of the world's almonds and mountains of hulls and shells — is one of the best launchpads on earth for the circular bioeconomy.
🎧 Listen to the full episode to hear the single biggest mistake founders make when following up with investors (and the "keep delighting us with news" approach that works instead), why aggressive AI-generated outreach lands you in the spam folder, how building in public and authenticity get investors to source you, what BEAM Circular looks for in an applicant, and the incentives that make the Central Valley — not just San Francisco — a place to scale.

Key Facts: BEAM Circular Accelerator (Powered by gener8tor)
Darko Mandich: https://www.linkedin.com/in/darkomandich
Websites: gener8tor.com · beamcircular.org
Program Base: Modesto, California 
Focus: Early- to mid-stage startups in biomanufacturing, waste transformation, and circular solutions across agriculture and natural resources — turning agricultural side streams (e.g., almond hulls and shells) into materials, fuels, ingredients, and chemicals.
Support (per company): ~$100K in combined support — a $15K non-dilutive grant, a $35K investment, and $50K in California Bioeconomy Innovation Campus credits — plus mentorship and partner perks.

Blurb
The BEAM CIRCULAR ACCELERATOR, powered by gener8tor, is built on a bet about geography and timing: that the next wave of the bioeconomy won't be built only in San Francisco or Boston, but in places like California's Central Valley — where 80% of the world's almonds are grown, and where the hulls, shells, and side streams once treated as waste are becoming feedstock for materials, fuels, ingredients, and chemicals. In partnership with the Modesto nonprofit BEAM Circular, the program pairs small, concierge cohorts with a shared California Bioeconomy Innovation Campus designed to remove the single biggest killer of deep-tech startups — CapEx — so founders don't have to burn venture dollars building their own pilot facilities.

Episode 114: Saku Biosciences: Mark van Zee on Raising Friends-and-Family in a Frozen Market, Betting on the Jockey, and Giving a VC Goosebumps in Five Minutes
In this episode, I sit down with Mark van Zee, Co-Founder & CEO of Saku Biosciences, who just closed a $940K round with Big Idea Ventures coming in as the institutional lead. It's a refreshingly different conversation for this show — instead of a later-stage playbook, Mark takes us all the way back to the very first checks, and how you actually raise when the market is frozen. Saku started fundraising two weeks after the tariff announcement that sent institutional capital "to zero," so Mark and his co-founder John got scrappy: friends-and-family checks of $5K–$100K that triggered a "pile-on" chain reaction, plus capital from a non-obvious private institution that took a year of relationship-building and ultimately saved the company. Mark reframes friends-and-family money not as a source of anxiety but as motivation — a commitment "in blood" — and makes the case that early-stage investing is betting on the jockey, not the horse. We close on one of the best fundraising stories I've heard: how the Saku team reverse-engineered exactly what Big Idea Ventures' decision-maker was looking for ("something that gives me goosebumps") and built a five-minute narrative to deliver it.
🎧 Listen to the full episode to hear why fundraising is more like dating than a transaction, how to unlock non-obvious capital that isn't promoted anywhere, why you sell to the associate and the partner completely differently, how Mark turned "I ride my bike to college classes at fourteen" into a goosebumps pitch, and why nobody in food tech has cracked the scalable-company code yet — but the wave is coming.

Key Facts: Saku Biosciences
Mark van Zee: https://www.linkedin.com/in/mark-van-zee-089910154
Website: sakubio.com
Headquarters: Los Angeles, California
Funding: $940K round (SAFE), with Big Idea Ventures as institutional lead (Global Food Innovation Fund II) — following a friends-and-family raise and capital from a private institutional source.

Blurb
SAKU BIOSCIENCES exists to fix a quiet but expensive failure in biomanufacturing: the strains companies screen in the lab are optimized for the lab, not for the fermentation tank they'll actually run in. That mismatch produces false positives, wasted scale-up campaigns, and stubbornly poor unit economics. Saku's PicoShells platform — hollow, porous hydrogel particles that isolate millions of strain variants and let them be tested under true bioreactor conditions — lets producers select for real-world manufacturing performance, and get to the cost parity that fermentation needs to displace incumbent animal- and plant-derived inputs.

Episode 113: Rainbow Crops: Giacomo Bastianelli on Treating Every Investor as "One Shot," Selling Without Selling, and Fundraising as a Probability Matrix
In this episode, I welcome back Giacomo Bastianelli, Co-Founder & CEO of Rainbow Crops — and one of the first founders to return to the podcast, because eighteen months ago we were talking about his pre-seed, and today he's just closed a €9.7M seed round plus a $7M grant from the Gates Foundation. Rainbow Crops is a VIB spin-off out of Ghent developing next-generation crop genetics, combining precision breeding, multiplex genome editing, and AI to tackle the complex, multi-gene traits — yield, stress resilience — that a single-gene approach can't touch. Giacomo walks us through how he ran the raise like a disciplined operator: preparing the seed materials before the pre-seed even closed, building a manually curated 60-name investor funnel in Trello, and treating every first interaction as a single shot he couldn't waste. He explains why his lead investor, Turin-based LIFTT, was nowhere on that list — and why doing the work is exactly what opens you up to that kind of serendipity. Along the way we get into a genuinely different take on persuasion for deep tech: honesty as a sales strategy, presenting risk as a probability matrix, and why the best salespeople never actually sell.
🎧 Listen to the full episode to hear why Giacomo built his own pitch deck instead of hiring an agency (and when a "polisher" makes sense), how he structured a results deck that lands for both non-technical investors and PhD experts, why you should pitch your tier-two and tier-three investors first, how he used a probabilistic model to talk investors through regulatory and patent risk, and the "tip of the iceberg" principle behind a deck that could survive real due diligence.

Key Facts: Rainbow Crops
Giacomo Bastianelli: https://www.linkedin.com/in/giacomob
Website: rainbowcrops.com
Headquarters: Ghent, Belgium
Funding: €9.7M seed round led by LIFTT (with LIFTT EuroInvest), alongside AIF, PINC, VIB, Corteva (via Corteva Catalyst), and Maia Ventures — plus a separate $7M grant from the Gates Foundation for climate-resilient corn and sorghum.

Blurb
RAINBOW CROPS is built on a hard genetic truth: the traits that matter most in agriculture — yield, drought tolerance, climate resilience — are almost never controlled by a single gene. They emerge from networks of genes interacting at once, which is precisely why they've resisted decades of conventional breeding and single-edit biotech. Rainbow Crops attacks that complexity head-on with its Trait Foundry™ platform, pairing multiplex genome editing with AI and automated phenotyping to search enormous combinatorial spaces and engineer the multi-gene traits that older tools simply can't reach.

Episode 112: Michroma & We Are Palta: Ricky Cassini and Alan Valicenti on Treating the Raise Like a Sales Process, the 110-Slide Data Room, and Turning Complex Into Compelling
In this episode, I sit down with two Argentinians who have been building together for almost six years: Ricky Cassini, Co-Founder & CEO of Michroma, the precision-fermentation startup making natural food colors from fungi, and Alan Valicenti, Partner & Chief Growth Officer of We Are Palta, the design-and-marketing agency built for science-driven deep-tech companies. It is a rare, candid look at what it actually costs — in dollars, in time, and in discipline — to make a deep-tech company look as serious as its science. Ricky breaks down how Michroma rebuilt its entire data room into roughly 110 professionally designed slides — carved into a teaser deck plus dedicated decks for market opportunity, the platform, the ingredients, regulatory, IP, team and advisory board, and techno-economics/manufacturing — and how that data room helped oversubscribe a $5M target into a $6.4M seed that investors said "looked like a Series B." Alan pulls back the curtain on how We Are Palta scopes and prices the work, why "subtracting" is the highest-value skill in an age of AI slop, and how one professional photoshoot and brochure flipped Michroma from radio silence to inbound sample requests — without changing the product at all.
🎧 Listen to the full episode to hear why Alex argues founders should budget roughly 10% of a raise toward actually raising it, why an in-house designer can't replace a multidisciplinary team that understands both biotech and what investors need to see, how We Are Palta turned a 110-slide master deck into five reusable decks plus website and commercial assets, why colorants that don't change taste still command a premium (and what that says about design), and the three questions every founder should ask before hiring an agency.
Key Facts: Michroma
Ricky Cassini: https://www.linkedin.com/in/cassinir/
Website: michroma.co
Headquarters: San Francisco, California and Argentina
What They Do: A precision-fermentation platform using fungal "biofactories" to produce natural food colors and flavors — led by the heat- and pH-stable natural red designed to replace synthetic Red 40.
Funding: ~$8M raised to date, anchored by a $6.4M seed round that oversubscribed an original $5M target (led by Supply Change Capital, with SOSV/IndieBio and a deep syndicate of strategic and food-industry investors).
Key Facts: We Are Palta
Alan Valicenti: https://www.linkedin.com/in/alanvalicenti/
Website: wearepalta.com
Headquarters: Argentina (operating globally)

Blurb
MICHROMA is built on a stubborn technical problem the food industry has never fully solved: natural colors tend to fall apart. They fade, shift, or break down under the heat, light, and pH swings of real manufacturing, which is why so much of the world's food supply still leans on petroleum-derived synthetic dyes like Red 40. Michroma's answer is biology. Using fungal "biofactories" and precision fermentation, the company brews natural colorants — starting with a heat- and pH-stable red — that are designed to survive the processing line and match the performance food makers expect from synthetics, at a cost that can compete rather than command a sustainability premium.

Episode 111: Twynam Management: Elissa Glorie on Out-Scoping University Research, Techno-Economics, and Avoiding False Assumptions
In this episode, I catch up with Elissa Glorie, Investment Manager at Twynam, a deeply specialized venture capital firm focused on early-stage global decarbonization. Elissa gives us an exclusive look behind the scenes of their thesis-driven investment engine, detailing how their team converts macroeconomic signals into actionable deep-tech bets. She walks us through Twynam’s recent high-profile follow-on into PlasmaLeap Technologies’ $20M USD (~A$30M) Series A, a round alongside the Bill & Melinda Gates Foundation and global nitrogen giant Yara Growth Ventures. Elissa breaks down their precise, gated due diligence playbook and provides critical advice on why the vast majority of deep-tech deals fall apart under the microscope of realistic technoeconomic models.🎧 Listen to the full episode to hear how Twynam’s internal AI tools scrape academic research before ideas even reach a corporate desk, why a CEO must possess the technical depth to cross-examine their CTO, and how Twynam evaluates decentralized, non-thermal plasma architectures against the centuries-old Haber-Bosch process.
Key Facts: Twynam
Elissa Glorie: https://www.linkedin.com/in/elissaglorie/
Website: twynam.com
Headquarter: Australia and Singapore
Geographic Mandate: Structurally built for true global deployment—actively tracking and backing winners across the US, India, and Southeast Asia, alongside a dedicated side-vehicle exclusively for the Chinese mainland.
Investment Sweet Spot: Pre-Seed through Series B, with standard, high-conviction initial checks scaling up to $3M USD.
Blurb
TWYNAM operates on a central, pragmatic insight: the global economy will not decarbonize out of moral virtue alone—it will decarbonize when clean technologies become undeniably better, faster, and cheaper than fossil incumbents. Rooted in decades of handling real physical assets like heavy industrial farming and mining loops, Twynam takes a rigorous, numbers-first approach to climate tech.
Their team spends half their time building highly detailed, forward-looking theses that anticipate structural bottlenecks before mainstream venture markets spot them. By utilizing custom-built AI discovery pipelines to scan global research data, Twynam uncovers breakthrough chemistry, engineering, and thermal physics plays at the university level, giving them a distinct first-mover advantage as an early institutional partner.