Cell & Gene: The Podcast

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Episode 141 of Cell & Gene: The Podcast features Host Erin Harris' discussion with Ali Pashazadeh, Founder, Chairman, and CEO of Treehill Partners, about the manufacturing challenges that continue to limit cell and gene therapy development. They explore why manufacturing feasibility, scale-up, and cost efficiency must be addressed early, how developers should approach CDMO partnerships, why operational planning must connect preclinical development through commercialization, and more. 
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In Episode 140 of Cell & Gene: The Podcast, Erin Harris speaks with Dr. Remo Moomiaie-Qajar of Axiom Biosciences about the company’s delivery-focused approach to developing regenerative and genetic medicines, including stem cell therapies, mRNA, and nanoparticles. Dr. Remo explains why drug delivery platforms can help shape therapeutic design and development strategy, and how evolving FDA guidance is creating opportunities to streamline preclinical requirements, leverage platform-based CMC data, and accelerate clinical development without compromising safety or quality. He also discusses the value of early regulatory engagement, clearer expectations, and stronger collaboration between developers and the FDA.
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On episode 139, Host Erin Harris talks to Jonathan Rigby, President and CEO of Sernova (and proposed CEO of BetaNova) and Will Rust, Ph.D., President and CEO of Seraxis (and proposed President and CSO of BetaNova). Sernova and Seraxis are coming together to form BetaNova, combining Sernova’s implantable Cell Pouch with Seraxis’ stem cell-derived pancreatic islet cells in an effort to develop a functional cell therapy for people living with Type 1 diabetes (T1D). They discuss the rationale behind the merger, the challenges of replacing insulin-producing cells at scale, and the strategies BetaNova is pursuing to address immune suppression and autoimmune rejection. They also discuss the company’s SRO2 and gene-edited SRO3 programs, the planned clinical path, and how the combined platform could advance the goal of a functional cure for T1D. 
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In episode 138 of Cell & Gene: The Podcast, EA Weeks, J.D., Ph.D., Counsel at Troutman Pepper Locke talks to Host Erin Harris about the deal terms that matter most in CGT, including IP ownership, manufacturing capacity, CMC milestones, data rights, tech transfer, and more. They also discuss planning for what happens when a partnership does not go as expected.
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In episode 137 of Cell & Gene: The Podcast, Host Erin Harris talks with Sylke Poehling, Ph.D., SVP and Global Head: Therapeutic Modalities, pRED; Roche Gene Therapy Center of Excellence about how the company selects the optimal modality by starting with disease biology. Dr. Poehling explains how an integrated Center of Excellence brings together discovery, safety, manufacturing, and development expertise to reduce technical risk and accelerate progress. She outlines where AI is already creating value versus where caution is warranted. She also explains why genomic medicines will become mainstream when, for common diseases, physicians can offer them as routine options and patients can choose them with confidence. 
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