This podcast describes the May 2026 JACI: In Practice issue, the theme of which is “Drug Allergy”. Theme articles described are on the topics of novel uses of digital health and the electronic medical record in drug allergy, novel approaches to ambulatory antibiotic allergy clinics, blistering drug eruptions, and allergy to penicillin, sulfonamides, vancomycin, and checkpoint inhibitors. The podcast also includes the Highlights of the Original Articles in the issue, which are on the topics of Drug Allergy, Asthma, Food Allergy, Immunodeficiency, Patient-reported Outcomes, Rhinitis, and Urticaria.