CNN One Thing

After the killings of two American citizens in Minneapolis and the firing of DHS Secretary Kristi Noem, the Trump administration’s immigration enforcement operation is attempting a bit of a reset. From calling ICE agents “NICE” agents on social media to reducing visible presence on the streets, it’s clear new Secretary Markwayne Mullin wants federal agents out of the spotlight. But are the goals of President Donald Trump’s mass deportation push any different? Plus, we hear from someone caught in the middle of the administration’s crackdown on legal immigration. 

For more: Exclusive: Trump moves to accelerate deportations of migrant children in US custody 

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Guest: Priscilla Alvarez, CNN Correspondent 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin 

Editorial Support: Tami Luhby

Photo: Matthew Hatcher/Getty Images
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King Charles is in the midst of a four-day state visit to the US to mark the 250th anniversary of US independence. The visit comes at a time when US-UK relations are notably strained, thanks to the war with Iran and calls for greater Jeffrey Epstein-related accountability. But President Donald Trump is usually receptive to royalty – so will this trip help mend fences, or give European allies more to worry about? 

For more: Epstein scandal lingers in background of King Charles’ visit to Washington 

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Guest: Jack Blanchard, POLITICO Playbook Author/Managing Editor 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin

Photo: Henry Nichols/Pool/AFP/Getty Images
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Tech titans Elon Musk and Sam Altman are set to face off in court this week in a case centered on OpenAI’s transition to a for-profit model. Musk alleges Altman and his company have strayed from their founding mission to develop artificial intelligence for the good of humanity rather than corporate profit (OpenAI denies the allegations). But is this just petty billionaire beef, or could it tell us something about our own AI futures?

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Guest: Hadas Gold, CNN AI Correspondent  

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin 

Photo: Carlos Barria/Kenny Holston/Pool/Reuters
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President Donald Trump signed an executive order on Saturday aimed at beefing up research of psychedelic drugs like ibogaine that could be used in mental health treatments. Some veterans and people who have struggled with addiction who have used ibogaine say this could be a breakthrough that could lead to wider access, but some medical experts are warning approvals shouldn’t be rushed. We hear why a leading advocate group says while it’s a good start – much more has to be done. 

For more: Trump accelerates research on psychedelic treatments and asks, ‘Can I have some?’ 

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Guests: Samantha Juan & Melissa Lavasani, Psychedelic Medicine Coalition Founder/CEO 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin 

Editorial Support: Katherine Dillinger

Photo: Jim Watson/AFP/Getty Images
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Roughly 95,000 employees left federal science agencies between September 2024 and December 2025, according to the Partnership for Public Service. Former NASA climate scientist Kate Marvel recently joined that group, citing the administration’s funding cuts and attacks on climate and environmental regulations in her resignation letter. However, she remains hopeful about the future of the study of climate change – if her fellow scientists are willing to get angry about it. 

For more: Trump admin is pulling supercomputers out of key weather and climate research center 

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Guest: Kate Marvel, former NASA climate scientist 

Host: David Rind 

Producer: Paola Ortiz 

Showrunner: Felicia Patinkin 

Editorial Support: Andrew Freedman

Photo: Reid Wiseman/NASA
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