Princeton UP Ideas Podcast

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Athena Aktipis, "The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer" (Princeton UP, 2020)
When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell: How Evolution Helps Us Understand and Treat Cancer (Princeton UP, 2020) delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it. Hussein Mohsen is a PhD/MA Candidate in Computational Biology and Bioinformatics/History of Science and Medicine at Yale University. His research interests include machine learning, cancer genomics, and the history of human genetics. For more about his work, visit http://www.husseinmohsen.com.
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57:38
David D. Hall, "The Puritans: A Transatlantic History" (Princeton UP, 2019)
This book is a sweeping transatlantic history of Puritanism from its emergence out of the religious tumult of Elizabethan England to its founding role in the story of America. Shedding critical new light on the diverse forms of Puritan belief and practice in England, Scotland, and New England, David D. Hall provides a multifaceted account of a cultural movement that judged the Protestant reforms of Elizabeth’s reign to be unfinished. Hall’s vivid and wide-ranging narrative describes the movement’s deeply ambiguous triumph under Oliver Cromwell, its political demise with the Restoration of the English monarchy in 1660, and its perilous migration across the Atlantic to establish a “perfect reformation” in the New World. A breathtaking work of scholarship by an eminent historian, The Puritans: A Transatlantic History (Princeton University Press, 2019) examines the tribulations and doctrinal dilemmas that led to the fragmentation and eventual decline of Puritanism. It presents a compelling portrait of a religious and political movement that was divided virtually from the start. In England, some wanted to dismantle the Church of England entirely and others were more cautious, while Puritans in Scotland were divided between those willing to work with a troublesome king and others insisting on the independence of the state church. This monumental book traces how Puritanism was a catalyst for profound cultural changes in the early modern Atlantic world, opening the door for other dissenter groups such as the Baptists and the Quakers, and leaving its enduring mark on what counted as true religion in America. Ryan Tripp is part-time and full-time adjunct history faculty for Los Medanos Community College as well as the College of Online and Continuing Education at Southern New Hampshire University.
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1:18:36
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1:18:36
Margaret C. Jacob, "The Secular Enlightenment" (Princeton UP, 2019)
The Secular Enlightenment by Professor Margaret C. Jacob, has been called a major new history on how the Enlightenment transformed people's everyday lives. It’s a panoramic account of the radical ways that life began to change for ordinary people in the age of Locke, Voltaire, and Rousseau. In this landmark book, familiar Enlightenment figures share places with voices that have remained largely unheard until now, from freethinkers and freemasons to French materialists, anticlerical Catholics, pantheists, pornographers, readers, and travelers. Jacob, one of our most esteemed historians of the Enlightenment, reveals how this newly secular outlook was not a wholesale rejection of Christianity but rather a new mental space in which to encounter the world on its own terms. She takes readers from London and Amsterdam to Berlin, Vienna, Paris, and Naples, drawing on rare archival materials to show how ideas central to the emergence of secular democracy touched all facets of daily life. Human frailties once attributed to sin were now viewed through the lens of the newly conceived social sciences. People entered churches not to pray but to admire the architecture, and some began to spend their Sunday mornings reading a newspaper or even a risqué book. The secular-minded pursued their own temporal and commercial well-being without concern for the life hereafter, regarding their successes as the rewards for their actions and their failures as the result of blind economic forces. A wonderful work of intellectual and cultural history, The Secular Enlightenment demonstrates how secular values and pursuits took hold of eighteenth-century Europe, spilled into the American colonies, and left their lasting imprint on the Western world for generations to come. Margaret Jacob is Distinguished Professor of History at the University of California, Los Angeles. Her many books include The Radical Enlightenment: Pantheists, Freemasons, and Republicans and The First Knowledge Economy: Human Capital and the European Economy, 1750-1850. Carrie Lynn Evans is a PhD student at Université Laval in Quebec City
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1:04:36
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1:04:36
William Marx, "Libraries of the Mind" (Princeton UP, 2025)
Erich Auerbach wrote his classic work Mimesis, a history of narrative from Homer to Proust, based largely on his memory of past reading. Having left his physical library behind when he fled to Istanbul to escape the Nazis, he was forced to rely on the invisible library of his mind. Each of us has such a library—if not as extensive as Auerbach’s—even if we are unaware of it. In this erudite and provocative book, William Marx explores our invisible libraries—how we build them and how we should expand them.Libraries, Marx tells us, are mental realities, and, conversely, our minds are libraries. We never read books apart from other texts. We take them from mental shelves filled with a variety of works that help us understand what we are reading. And yet the libraries in our mind are not always what they should be. The selection on our mental shelves—often referred to as canon, heritage, patrimony, or tradition—needs to be modified and expanded. Our intangible libraries should incorporate what Marx calls the dark matter of literature: the works that have been lost, that exist only in fragments, that have been repurposed by their authors, or were never written in the first place. Marx suggests methods for recovering this missing literature, but he also warns us that adding new titles to our libraries is not enough. We must also adopt a new attitude, one that honors the diversity and otherness of literary works. We must shed our preconceptions and build within ourselves a mental world library. William Marx is professor of comparative literature at the Collège de France. He is the author of The Hatred of Literature, The Tomb of Oedipus: Why Greek Tragedies Were Not Tragic, and other books. Morteza Hajizadeh is a Ph.D. graduate in English from the University of Auckland in New Zealand. His research interests are Cultural Studies; Critical Theory; Environmental History; Medieval (Intellectual) History; Gothic Studies; 18th and 19th Century British Literature. YouTube channel. Twitter.
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1:05:38
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1:05:38
On Bullshit in AI
Today we’re continuing our series on Harry Frankfurt’s seminal work, On Bullshit. I have the privilege to speak with Arvind Narayanan co-author of the book AI Snake Oil: What Artificial Intelligence Can Do, What it Can’t, and How to Tell the Difference (Princeton University Press, 2024). Arvind is the perfect guest to explore the subject of bullshit in AI as AI Snake Oil takes on the ridiculous hype ascribed to the promise of AI. AI chatbots often hallucinate and many of the promoters of AI engage in the art of bullshit when selling people on wild and crazy AI applications. Arvind Narayanan is professor of computer science at Princeton University and director of its Center for Information Technology Policy. Caleb Zakarin is editor of the New Books Network.
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