Talk Python To Me

Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state.



This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show

marimo pair: marimo.io/pair

Course transcripts announcement: talkpython.fm/blog

anywidget: Jupyter Widgets made easy: talkpython.fm

marimo: marimo.io

blog: marimo.io

GitHub: github.com

given this: martinalderson.com

llms.txt: talkpython.fm

mcp: talkpython.fm

cli: talkpython.fm

open issues: github.com

Discord: marimo.io

Marimo Pair: marimo.io

OpenCode: opencode.ai

AI Tooling for Software Engineers in 2026: newsletter.pragmaticengineer.com

Watch this episode on YouTube: youtube.com

Episode #555 deep-dive: talkpython.fm/555

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it.

Episode sponsors

Six Feet Up

Talk Python Courses

Links from the show

Guest

Sumit Gundawar: linkedin.com

Course transcripts announcement: talkpython.fm/blog

Sumit Gundawar - JAX London Speaker: jaxlondon.com

Anthropic: anthropic.com

OpenAI Platform: platform.openai.com

Anthropic: anthropic.com

LangChain: langchain.com

OWASP: owasp.org

Pydantic: pydantic.dev

EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu

HIPAA - HHS: www.hhs.gov

NHS: www.nhs.uk

Llama: llama.com

Qwen - QwenLM on GitHub: github.com

OpenAI Platform: platform.openai.com

Hugging Face: huggingface.co

Llama: llama.com

Granola: www.granola.ai

HIPAA - HHS: www.hhs.gov

CodeRabbit: www.coderabbit.ai

Cursor Origin: cursor.com

GitHub Status: www.githubstatus.com

Midjourney Medical: www.midjourney.com

Neko Health: www.nekohealth.com

CERN: home.cern

ATLAS Experiment: atlas.cern

Watch this episode on YouTube: youtube.com

Episode #554 deep-dive: talkpython.fm/554

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Python in Production

Talk Python Courses

Links from the show

@calvinhp@sixfeetup.social: sixfeetup.social

@calvinhp.com: bsky.app

calvinhp.com: calvinhp.com

Original airing on Python Bytes: pythonbytes.fm

pi: pi.dev

superpowers: github.com

Warp.dev: Warp.dev

OhMyZSH: ohmyz.sh

Commandbookapp.com: Commandbookapp.com

Blink: blink.sh

kitty: sw.kovidgoyal.net

mosh: mosh.org

tmux: github.com

Claude code: www.anthropic.com

Claude.md: Claude.md

MacWhisper: goodsnooze.gumroad.com

Handy: handy.computer

Tailscale: tailscale.com

Talk Python episode with Alex: talkpython.fm

Telescopo: www.telescopo.app

Typora markdown: typora.io

formal documentation for many of my open source packages: mkennedy.codes

Great Docs: posit-dev.github.io

Statement on the US government directive to suspend access to Fable 5 and Mythos 5: www.anthropic.com

No second date: x.com

Watch this episode on YouTube: youtube.com

Episode #553 deep-dive: talkpython.fm/553

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe.

Episode sponsors

Sentry Error Monitoring, Code talkpython26

Talk Python Courses

Links from the show

Guest

Charlie Marsh: github.com

The announcement: astral.sh

OpenAI: openai.com

uv: github.com

ty: github.com

Ruff: github.com

pyx: astral.sh

Codex team: openai.com

Anthropic did something similar by acquiring Bun: www.anthropic.com

Daily Stars Explorer: emanuelef.github.io

Agentic AI Programming for Python: training.talkpython.fm

Python Web Security: OWASP Top 10 with Agentic AI: training.talkpython.fm

Episode #552 deep-dive: talkpython.fm/552

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

Episode sponsors

AgentField AI

Talk Python Courses

Links from the show

Guests

Naunidh Bhalla: linkedin.com

Grant Gittes: linkedin.com

Marcel Kornacker: linkedin.com

Beon de Nood: linkedin.com

Chinmaya Joshi: linkedin.com

David Mytton: linkedin.com

Shea Tate-Di Donna: linkedin.com

Jason Rowley: linkedin.com

Azul Garza: github.com

Renée Rosillo: linkedin.com

Tetrix: tetrix.co

Tetrix Jobs: tetrix.co

Arcjet: arcjet.com

Pixeltable: pixeltable.com

Phemeral.dev: phemeral.dev

CapiscIO: capisc.io

Episode #551 deep-dive: talkpython.fm/551

Episode transcripts: talkpython.fm

Theme Song: Developer Rap

🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---

YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm

Mastodon: @talkpython@fosstodon.org

X.com: @talkpython

Michael on Bluesky: @mkennedy.codes

Michael on Mastodon: @mkennedy@fosstodon.org

Michael on X.com: @mkennedy